CAS: 1466-83-7; N-Benzoyl-L-Leucine

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📜Dl-亮氨酸置于sodium Hydroxide,葡萄糖,Corn Steep Liquor,Fungus Beauveria Bassiana Atcc 7159体系中,用 乙醇,水 用作溶剂,化学反应 74.0H,反应生成N-苯甲酰-L-亮氨酸
参考文献:Beauveria Bassiana Atcc 7159 Containsan L-Specific A-Amino Acid Benzamidase
标题:Beauveria Bassiana Atcc 7159 Containsan L-Specific A-Amino Acid Benzamidase
摘要:Biotransformation Of A Series Of Racemic N-Benzoyl Alpha-Amino Acids By The Fungus Beauveria Bassiana Atcc 7159 Results In Isolation Of The Corresponding D-Amino Acid Benzamides In High Enantiomeric Purity And Yield.
Doi:10.1007/s007060070095

专利信息

专利号:US-5202235-A
优先权日:1986-08-18
标题 :Enzymatic method for the synthesis and separation of peptides
发明人：IACOBUCCI GUILLERMO A
权利人:COCA COLA CO
摘要:The present invention provides a method for the enzymatic synthesis of peptides accomplished by shifting the chemical equilibrium that exists in a reaction mixture between charged or ionized reacting amino acids and uncharged or non-ionized peptide product in the presence of a proteolytic enzyme such as thermolysin. The equilibrium is shifted by diffusion of the uncharged peptide product across an ion-rejection membrane which removes the uncharged peptide from the reaction mixture and preferably the diffused uncharged peptide is quickly converted to a charged species that cannot back-diffuse into the reaction mixture so that the uncharged peptide is effectively 'pulled' across the membrane.

专利号:US-5350681-A
优先权日:1986-08-18
标题 :Enzymatic membrane method for the synthesis and separation of peptides
发明人：IACOBUCCI GUILLERMO A; BROSE DANIEL J; RAY RODERICK J; VAN EIKEREN PAUL
权利人:COCA COLA CO
摘要:The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha carboxylate group is reacted with a protected peptide having an N-terminal ammonium group or a protected amino acid having an alpha ammonium group in the presence of a condensation enzyme under conditions in which the carboxylate group and the ammonium group condense to form a protected, uncharged, peptide product. This peptide product is transported across a water-immiscible hydrophobic phase into an aqueous product phase and prevented from back diffusing across the water-immiscible hydrophobic phase. The peptide product can be converted, chemically or enzymatically, to a charged species that cannot back diffuse across the water-immiscible phase into the aqueous reaction phase. The water-immiscible hydrophobic phase is an ion rejection membrane separating the aqueous reaction phase from the product phase creating oil/water interfaces with each of the aqueous phases.

专利号:US-5002871-A
优先权日:1986-08-18
标 题:Enzymatic membrane method for the synthesis and separation of peptides
发明人：IACOBUCCI GUILLERMO A
权利人:COCA COLA CO
摘要:The present invention provides a membrane method for the enzymatic synthesis of peptides accomplished by shifting the chemical equilibrium that exists in a reaction mixture between charged or ionized reacting amino acids and uncharged or non-ionized peptide product in the presence of a proteolytic enzyme such as thermolysin. The equilibrium is shifted by diffusion of the unchanged peptide product across an ion-rejection membrane which removes the uncharged peptide from the reaction mixture and preferably the diffused uncharged peptide is quickly converted to a charged species that cannot back-diffuse into the reaction mixture so that the uncharged peptide is effectively 'pulled' across the membrane. An enzymatic conversion of the uncharged species utilizing an esterase having proteolytic activity such as aminoacylase I is disclosed. Copermeating reactants can be separated from the product mixture and returned to the reaction mixture. Also, the ion-rejection membrane can be utilized to resolve enantiomers of racemic carboxylic acids including D,L-amino acids.

专利号:US-10676423-B2
优先权日:2017-02-21
标题 :Structure and synthesis of highly fluorinated amino acid derivatives
发明人：WEAVER JIMMIE DEAN; TEEGARDIN KIP ALLEN; ARORA AMANDEEP
权利人:UNIV OKLAHOMA STATE
摘要:Methods of synthesizing polyfluorinated amino acid derivatives are disclosed, along with polyfluorinated amino acid derivatives produced from said methods, as well as compositions containing same. The synthesis methods utilize an oxazolone and a perfluoroarene to produce the polyfluorinated amino acid derivatives.

专利号:US-8124794-B2
优先权日:2002-04-17
标题:Method for the asymmetric synthesis of beta-lactone compounds
发明人：SMITH JEFFREY W; AXELROD FUMIKO; KRIDEL STEVEN J; ROMO DANIEL; PUROHIT VIKRAM; MA GIL
权利人:SMITH JEFFREY W; AXELROD FUMIKO; KRIDEL STEVEN J; ROMO DANIEL; PUROHIT VIKRAM; MA GIL; SANFORD BURNHAM MED RES INST
摘要:The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

专利号:US-5336601-A
优先权日:1986-08-18
标 题:Enzymatic membrane method for the snythesis and separation of peptides
发明人：IACOBUCCI GUILLERMO A
权利人:COCA COLA CO
摘要:The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha carboxylate group is reacted with a protected peptide having an N-terminal ammonium group or a protected amino acid having an alpha ammonium group in the presence of a condensation enzyme under conditions in which the carboxylate group and the ammonium group condense to form a protected, uncharged, peptide product. This peptide product is transported across a water-immiscible hydrophobic phase into an aqueous product phase. This peptide product is removed from the aqueous product phase to prevent back diffusion across the water-immiscible hydrophobic phase. Reverse osmosis and other separation techniques may be utilized to remove the peptide product. The water-immiscible hydrophobic phase is an ion rejection membrane separating the aqueous reaction phase from the product phase creating oil/water interfaces with each of the aqueous phases.