CAS: 142404-84-0; 2-Acetylamino-5-Bromo-6-Methylpyridine

该化合物是一种环环环的环状七环有机化合物,代之以2,5和6个位置;2位置的乙基氨基化合物的存在有助于其在有机合成中的活性及潜在应用;5位置的溴原子引入了嗜电特性,使其在各种化学反应中有用,包括核生殖替代;6位置的甲基组增加了该化合物的防水性质,能够影响其溶解性和与生物系统的互动;该化合物一般在室温下固态,在标准条件下可能表现出中度至高度稳定;其独特的结构允许其在制药,农用化学品和材料科学中的潜在应用;与许多溴化化合物一样,必须谨慎处理,因为含有溴的物质可能对环境和健康产生影响.

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142404-82-8 7169-97-3 5327-33-3

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上下游产品

5-bromo-6-methyl-pyridin-2-ylamine acetic anhydride 2-acetylamino-6-methylpyridine sodium acetate 6-acetamido-3-bromopicolinic acid N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetamide

合成工艺路线路线简述

    📜2-乙酰氨基-6-甲基嘧啶置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,用 水 用作溶剂,化学反应 1.0H,以90%的收率获得2-乙酰氨基-5-溴-6-甲基吡啶
    参考文献:在有水或无水情况下某些杂环的n-溴琥珀酰亚胺反应:合成重要的溴化杂环合成子的环对溴与侧链溴化的概述
    标题:在有水或无水情况下某些杂环的n-溴琥珀酰亚胺反应:合成重要的溴化杂环合成子的环对溴与侧链溴化的概述
    摘要:对于侧链与环溴化反应,研究了各种杂环1-6与n-溴琥珀酰亚胺在有水或无水条件下的反应,以提供一些新的重要的杂环合成子.有趣的是,在高氯酸存在下的n-溴琥珀酰亚胺反应(一种新条件)仅提供了新的二溴氨基吡啶1F,这是目前其他研究方法无法获得的.
    Doi:10.1002/jhet.5570380125

    海关参考信息

    专利信息


    专利号:EP-0842924-B1
    优先权日:1996-11-14
    标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists
    发明人：WRIGHT STEPHEN WAYNE
    权利人:PFIZER
    摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o

    专利号:US-6008361-A
    优先权日:1996-04-09
    标题:Substituted pyridines
    发明人：WRIGHT STEVEN W
    权利人:PFIZER
    摘要:The present invention relates to certain compounds of the formula (I), ##STR1## which are useful in the synthesis of certain β-adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), ##STR2## wherein R 1 , R 2 and R 4 are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), ##STR3## R 1 , R 2 and Y 2* are defined herein.

    专利号:US-6031105-A
    优先权日:1996-04-09
    标题:Substituted pyridines
    发明人：WRIGHT STEVEN W
    权利人:PFIZER
    摘要:The present invention relates to certain compounds of the formula (I), ##STR1## which are useful in the synthesis of certian β-adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), ##STR2## wherein R 1 , R 2 and R 4 are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), ##STR3## R 1 , R 2 and Y 2* are defined herein.

    专利号:ES-2203762-T3
    优先权日:1996-11-14
    标题:INTERMEDIATE PYRIDINS USEFUL IN THE SYNTHESIS OF AGONISTS OF THE BETA ADRENERGIC RECEIVER

    专利号:EP-0842924-A1
    优先权日:1996-11-14
    标题:Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists

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    合成参考文献

    参考DOI号:10.1021/jo0402226
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