CAS: 127-17-3; 2-Oxopropanoic Acid

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CAS号79-41-4 甲基丙烯酸 | CAS号57-55-6 丙二醇 | CAS号78-98-8 丙酮醛 | CAS号471-25-0 丙炔酸 | CAS号124-38-9 二氧化碳 | CAS号75-07-0 乙醛 | CAS号113-24-6 丙酮酸钠 | CAS号1195577-61-7 S-Allyl-D-cyste... | CAS号551958-89-5 2-benzyl-2-hydr... | CAS号600-18-0 2-丁酮酸 | CAS号1113-60-6 羟基丙酮酸 | CAS号64-18-6 甲酸 | CAS号79-14-1 羟基乙酸 | CAS号849585-22-4 2-羟基丙酸 | CAS号463-79-6 碳酸钇二水 | CAS号7664-41-7 氨 | CAS号64-19-7 冰醋酸 | CAS号302-72-7 DL-2-氨基丙酸 | CAS号74-89-5 氨基甲烷 | CAS号500346-26-9 7-氯-8-甲基-2-苯基喹啉-4-羧酸

3-(甲基硒基)-L-丙氨酸置于phosphate Buffer,Crotalus Adamanteus L-Amino Acid Oxidase,2-(氨基氧基)乙酸体系中,化学反应 0.33H,反应生成丙酮酸
参考文献:化学预防性硒代半胱氨酸se-缀合物和相关氨基酸的生物激活作用通过氨基酸氧化酶进行硒代氨基酸代谢的新途径.
标题:化学预防性硒代半胱氨酸se-缀合物和相关氨基酸的生物激活作用通过氨基酸氧化酶进行硒代氨基酸代谢的新途径.
摘要:在化学致癌的动物模型中,几种硒代半胱氨酸se缀合物已显示具有有效的化学预防活性.作为作用机理,已经提出了形成化学预防的硒醇,氨和丙酮酸的β-消除反应.但是,已经部分阐明了与这些β-消除反应有关的酶.除半胱氨酸缀合的β-裂解酶外,尚未鉴定的非吡咯醛-5'-磷酸依赖性酶也似乎参与了胞质β-消除反应.在本研究中,研究了氨基酸氧化酶是否有助于硒代半胱氨酸硒结合物的生物活化.使用来自金鳄属的纯化l-氨基酸氧化酶作为模型酶,与se-甲基硒代半胱氨酸(k(m),195 Microm; K(cat),48 Min(-1)),Se-烯丙基硒代半胱氨酸(k(m),608 Microm; K( Cat),34分钟(-1)),Se-苯基硒代半胱氨酸(k(m),107 Microm; K(cat),57 Min(-1))和se-苄基硒代半胱氨酸(k(m),59 Microm; K( Cat),13分钟(-1)).对
Doi:10.1021/tx000265R

专利信息

专利号:US-9512420-B2
优先权日:2013-10-16
标题:Use of N-acetylneuraminic acid aldolase in catalytic synthesis of N-acetylneuraminic acid
发明人：XIE JINGJING; JI WENYAN; YING HANJIE; Sun wujin; GUO TING; CHEN YONG; CHEN XIAOCHUN; WU JINGLAN
权利人:NANJING UNIV OF TECH; NANJING UNIVERSITY OF TECHNOLOGY
摘要:It discloses a use of N-acetylneuraminic acid aldolase with an amino acid sequence as shown in SEQ ID NO: 2 in catalytic synthesis of N-acetylneuraminic acid. The preparation of N-acetylneuraminic acid is to use the N-acetylneuraminic acid aldolase with the amino acid sequence as shown in SEQ ID NO: 2 as a catalyst, and N-acetylmannosamine and pyruvic acid as substrates.

专利号:US-8153839-B2
优先权日:2005-09-14
标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound
发明人：OGO SEIJI; FUKUZUMI SHUN-ICHI
权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY
摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.

专利号:US-6168931-B1
优先权日:1999-03-17
标题 :Enhanced in vitro synthesis of biological macromolecules using a novel ATP regeneration system
发明人：SWARTZ JAMES R; KIM DONG-MYUNG
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of biological molecules where ATP is required for synthesis. Of particular interest is the synthesis of polymers, e.g. nucleic acids, polypeptides, and complex carbohydrates. A homeostatic system is used for production of ATP, where the required high energy phosphate bonds are generated in situ, e.g. through coupling with an oxidation reaction. The homeostatic energy source will typically lack high energy phosphate bonds itself, and will therefore utilize free phosphate in the reaction mix during generation of ATP. Since inorganic phosphate can be an inhibitory by-product of synthesis, the period of time when synthesis is maintained in vitro can be extended. The homeostatic energy source is provided in combination with an enzyme that catalyzes the creation of high energy phosphate bonds and with an enzyme that can use that high energy phosphate bond to regenerate ATP.

专利号:US-7928223-B2
优先权日:2008-06-20
标题:Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n n n n n n n n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8927708-B2
优先权日:2013-03-26
标 题 :Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine
发明人：LE FLOHIC ALEXANDRE
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nwherein R represents a para-methoxybenzyl (PMB) group or the following group:n n nApplication in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-4902817-A
优先权日:1987-09-17
标 题 :Process for the synthesis of alpha n alkylated amino acids and esters thereof, application to the synthesis of carboxyalkyl dipeptides
发明人：VINCENT MICHEL; BALIARDA JEAN; MARCHAND BERNARD; REMOND GEORGES
权利人:ADIR
摘要:Stereoselective process for the industrial synthesis of compounds of formula (I): ##STR1## where R 1 is linear or branched lower alkyl with 1 to 6 carbon atoms, n R 2 is a linear or branched lower alkyl with 1 to 4 carbon atoms, n employing inexpensive starting materials and obtaining optimum yields. n Application to the synthesis of carboxyalkyl dipeptides.