CAS: 122647-31-8; Ibutilide

上下游产品

N-[{4-(N-Ethyl-N-Heptylamino)Butanoyl}Phenyl]Methanesulfonamide 130350-55-9
N-(4-(1-Hydroxyallyl)Phenyl)Methanesulfonamide 863029-84-9
N-乙基-N-庚基-4-[(甲磺酰氨基)苯基]-4-氧代丁酰胺 N-Ethyl-N-Heptyl-γ-Oxo-4-<(Methylsulfonyl)Amino>Benzenebutanamide 100632-58-4
4-[(4-甲磺酰胺基)苯基]-4-氧代丁酸 4-<(Methylsulfonyl)Amino>-γ-Oxobenzenebutanoic Acid 100632-57-3

📜N-乙基-2-吡咯烷酮置于盐酸,Aluminum (III) Chloride,Lithium Aluminium Tetrahydride,氯化亚砜,水,Sodium Hydroxide体系中,用 四氢呋喃,二硫化碳,二氯甲烷,水 用作溶剂,化学反应 25.0H,反应生成伊布利特
参考文献:A Novel Synthesis Of Ibutilide Fumarate
标题:A Novel Synthesis Of Ibutilide Fumarate
摘要:一种新颖的伊布利特富马酸盐(消旋体)合成协议已从2-吡咯烷酮实现,总体产率为15%.核心结构在一步骤中基于friedel-Crafts酰基化反应构建,使用含有氨基盐酸盐的酰氯.
Doi:10.2174/157017811796064412

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-7220884-B2
优先权日:2004-02-10
标 题 :Hydroaminomethylation of olefins
发明人：BRIGGS JOHN R; WHITEKER GREGORY T; KLOSIN JERZY
权利人:DOW GLOBAL TECHNOLOGIES INC
摘要:The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2006074032-A1
优先权日:2000-11-29
标题 :Synthesis and separation of optically active isomers of erythromycin and their biological actions
发明人：SOMBERG JOHN; RANADE VASANT
权利人:ACADEMIC PHARM INC
摘要:The present invention provides methods for purifying and using optically active isomers of erythromycin as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions as an antibiotic substantially separable from undesirable effects on GI motility and the cardiac potassium channels such that the cardiac action potential is not prolonged and the QT interval on the surface EKG (electrocardiogram) is not increased, such that the erythromycin can be useful for more effective therapy of systemic infections. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.

专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications