CAS: 107362-12-9; (S)-2-Ethoxy-4-[2-({2-Phenyl-1-[2-(Piperidin-1-yl)Phenyl]Ethyl}Amino)-2-Oxoethyl]Benzoic Acid

该化合物是公认的Repaglinide杂质,一种短效胰岛素秘密教学机构,用于糖尿病管理,该化合物在结构上与Repaglinide有关,但缺乏2级异丙基组,代之以苯胺.该化合物是药物质量控制中的关键参考标准,确保了Repaglinide配方的纯度和安全.其特性精密的结构和高纯度使得它对于分析方法的开发,稳定性研究以及监管合规具有价值.通过促进精确的不纯度特征分析,该化合物有助于满足严格的药用要求,支持稳健的制造过程和一致的药物性能.该化合物的用途强调在API生产中遵守良好制造做法.

英文名称(S)-2-Ethoxy-4-[2-({2-Phenyl-1-[2-(Piperidin-1-yl)Phenyl]Ethyl}Amino)-2-Oxoethyl]Benzoic Acid
中文名称瑞格列奈相关物质C
其它别名REPAGLINIDE RELATED COMPOUND C (25 MG) ((S)-2-ETHOXY-4-[2-[[2-PHENYL-1 -[2-(1 -PIPERIDINYL)PHE-NYL]ETHYL]AMINO]-2-OXOETHYL] BENZOIC ACID); Repaglinide Related Compound C (25 mg) ((S)-2-Ethoxy-4-[2-[[2-phenyl-1-[2-(1-piperidinyl)phenyl]ethyl]amino]-2-oxoethyl] benzoic acid); (S)-2-Ethoxy-4-[2-[[2-phenyl-1-[2-(1-piperidinyl)phenyl]ethyl]aMino]-2-oxoethyl] benzoic acid; Repaglinide Related CoMpound C; 2-Desisopropyl-2-phenyl Repaglinide (Repaglinide IMpurity)
CAS编号107362-12-9
FDA UNII编号:QVW9L5V2LY
分子式:C30H34N2O4分子量:486.6
产品CID: 112500
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: MHMMEOVDUOZDJA-SANMLTNESA-N
1S/C30H34N2O4/c1-2-36-28-20-23(15-16-25(28)30(34)35)21-29(33)31-26(19-22-11-5-3-6-12-22)24-13-7-8-14-27(24)32-17-9-4-10-18-32/h3,5-8,11-16,20,26H,2,4,9-10,17-19,21H2,1H3,
计算化学: 氢键受体数5.0氢键供体数2.0可旋转键数10.0

MSDS等安全信息

上下游产品

(±)-2-Phenyl-1-[2-(Piperidin-1-yl)Phenyl]Ethylamine 107362-46-9

合成工艺路线路线简述

📜2-(1-哌啶基)苯甲腈置于盐酸,Sodium Tetrahydroborate,草酰氯,碘,Magnesium,Sodium Hydroxide体系中,用四氢呋喃,甲醇,环己烷,水,丙酮,甲苯用作溶剂,化学反应 27.0H,反应生成瑞格列奈相关物质c
参考文献:Synthesis Of Repaglinide Congeners
标题:Synthesis Of Repaglinide Congeners
摘要:This Report Describes A Synthesis Of Two Potent Impurities Of Repaglinide,Benzyl Repaglinide 1 And Repaglinide Isomer 2,From Commercially Available Raw Materials: 2-Fluoro Benzonitrile,(S)-3-Methyl-1-[2-(Piperidin-1-yl)Phenyl]Butylamine (5),And 3-Ethoxy-[4-(Ethoxycarbonyl)Phenyl]Acetic Acid (7). These Impurities Are The Crucial Components In Determining The Quality Of The Drug Substance,Repaglinide,During Its Manufacturing.
Doi:10.1080/00397911.2015.1064139