CAS: 106518-63-2; (5R,10S,13R,14R,17R)-4,4,10,13,14-Pentamethyl-17-((2R,5S)-5,6,7-Trihydroxy-6-Methylheptan-2-yl)-1,2,4,5,6,10,12,13,14,15,16,17-Dodecahydro-3H-Cyclopenta[a]Phenanthren-3-One
- 英文名称(5R,10S,13R,14R,17R)-4,4,10,13,14-Pentamethyl-17-((2R,5S)-5,6,7-Trihydroxy-6-Methylheptan-2-yl)-1,2,4,5,6,10,12,13,14,15,16,17-Dodecahydro-3H-Cyclopenta[a]Phenanthren-3-One
- 中文名称灵芝马酮
- IUPAC名称(5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-((2R,5S)-5,6,7-trihydroxy-6-methylheptan-2-yl)-1,2,4,5,6,10,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
- 其它别名Ganodermanontriol; Ganodermanontriol(Sh); Gadermantriol; (5R,10S,13R,14R,17R)-4,4,10,13,14-Pentamethyl-17-[(2R,5S)-5,6,7-Trihydroxy-6-Methylheptan-2-Yl]-1,2,5,6,12,15,16,17-Octahydrocyclopenta[a]Phenanthren-3-One; Lanosta-7,9(11)-Dien-3-One,24,25,26-Trihydroxy-, (24S,25R)-
- CAS编号106518-63-2
- MFCD编号:MFCD32901050
- FDA UNII编号:6NB33MKR8F
- 分子式:C30H48O4分子量:472.71
- 产品CID: 105198
- 产品分类天然产物 → 萜类
物理性质
- 沸点623.2±55.0 °C at 760 mmHg
- 闪点344.7±28.0 °C
- 密度1.1±0.1 g/cm3
- PSA:77.76
- LogP:5.66
- 折射率1.559
- 蒸汽压0.0±4.1 mmHg at 25°C
- 溶解性Chloroform: Soluble
- 外观形态粉末
- 储存条件-20°C
- 产品应用该化合物是G.CLEARYUM发现的一种三叶杆,具有多种生物活动,抑制了HIV-1蛋白(IC50=70微米)的活动,并且将5Α-呼吸酶的活性在667微米浓度时减少了32%. GANODERENONTIROL(25和50微米)抑制了MDA-MB-231人类乳腺癌细胞的扩散,聚居形成,入侵和迁移,在LPS/D-GALACTOS类动物的鼠标模型下,它减少了肝细胞细胞坏死,并在5毫克/千克剂量下,降低了肝细胞TNF-Α和IL-6水平.
MSDS等安全信息
上下游产品
ethyl (6R,E)-2-methyl-6-((5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3-oxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hept-2-enoate ethyl (6R,E)-2-methyl-6-((5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3-oxotetradecahydro-1H-8,9-epoxycyclopenta[a]phenanthren-17-yl)hept-2-enoate ethyl (6R,E)-2-methyl-6-((5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3-oxo-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)hept-2-enoate ethyl (6R,E)-2-methyl-6-((5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-1,2,4,5,6,10,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl)hept-2-enoate合成工艺路线路线简述
📜(5R,10S,13R,14R,17R)-17-((R,Z)-7-Hydroxy-6-Methylhept-5-En-2-yl)-4,4,10,13,14-Pentamethyl-4,5,6,10,12,13,14,15,16,17-Decahydro-1H-Cyclopenta[a]Phenanthren-3(2H)-One置于甲基磺酰胺,Ad-Mix β体系中,用 水,叔丁醇 用作溶剂,化学反应 6.0H,以76%的收率获得灵芝马酮
参考文献:Process For Preparing Delta-7,9(11) Steroids From Ganoderma Lucidum And Analogs Thereof
标题:Process For Preparing Delta-7,9(11) Steroids From Ganoderma Lucidum And Analogs Thereof
摘要:描述了从药用蘑菇灵芝中制备鲁氏萜类化合物的过程,以及相关化合物.还描述了用于治疗癌症的化合物,组合物和方法.
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: M P, Reddy GJ, Hema K, Dodoala S, Koganti B. Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies. Eur J Pharmacol. 2021 Jan 5;890:173688. doi: 10.1016/j.ejphar.2020.173688. Epub 2020 Oct 29.
2: Bharadwaj S, Lee KE, Dwivedi VD, Yadava U, Panwar A, Lucas SJ, Pandey A, Kang SG. Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease. Sci Rep. 2019 Dec 13;9(1):19059. doi: 10.1038/s41598-019-55723-5.
3: Hu Z, Du R, Xiu L, Bian Z, Ma C, Sato N, Hattori M, Zhang H, Liang Y, Yu S, Wang X. Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury. Cytokine. 2020 Mar;127:154917. doi: 10.1016/j.cyto.2019.154917. Epub 2019 Nov 24. 14(Supplement):S964-S968. doi: 10.4103/0973-1482.203597. 14(4):3273-3278. doi: 10.3892/etm.2017.4883. Epub 2017 Aug 3.
合成参考文献
参考文献:10.1615/intjmedmushrooms.v1.i2.40
摘要:Chen R, Yu D. Studies on the Triterpenoid Constituents of the Spores of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae). Int J Med Mushrooms. 1999;1(2):147–52. doi: 10.1615/intjmedmushrooms.v1.i2.40.
参考文献:10.1021/np50048a029
摘要:Fujita A, Arisawa M, Saga M, Hayashi T, Morita N. Two New Lanostanoids from Ganoderma lucidum. J. Nat. Prod. 1986 Nov;49(6):1122–5. doi: 10.1021/np50048a029.
📝 需求与反馈
尽可能描述清楚需求与问题信息
