CAS: 1062169-56-5; Methyl 4-(6-(4-((Methoxycarbonyl)Amino)Phenyl)-4-Morpholino-1H-Pyrazolo[3,4-D]Pyrimidin-1-yl)Piperidine-1-Carboxylate

上下游产品

methanol bis(trichloromethyl) carbonate methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

📜甲醇,三光气,Methyl 4-[6-(4-Aminophenyl)-4-Morpholin-4-Yl-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Piperidine-1-Carboxylate置于三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 0.08H,以23%的收率获得wye 354; 4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-D]嘧啶-1-基]-1-哌啶羧酸甲酯
参考文献:雷帕霉素哺乳动物靶标的atp竞争性抑制剂:高强度和选择性吡唑并嘧啶的设计和合成
标题:雷帕霉素哺乳动物靶标的atp竞争性抑制剂:高强度和选择性吡唑并嘧啶的设计和合成
摘要:雷帕霉素(mtor)的哺乳动物靶标是生长,存活和代谢的主要调节剂,是经过验证的癌症治疗靶标.雷帕霉素及其类似物(mtor的变构抑制剂)仅部分抑制一种mtor蛋白复合物.描述了具有增强抗癌功效潜力的atp竞争性mtor整体抑制剂.鉴定并完善了导致效价和选择性的结构特征,从而在肿瘤异种移植模型中产生了具有体内功效的化合物.
Doi:10.1021/jm900851F

专利信息

专利号:CN-108379591-B
优先权日:2018-04-03
标 题 :Synthesis of Immune Agonist Targeting Compounds and Their Applications

专利号:US-11285169-B2
优先权日:2013-03-13
标题 :Methods for modulating chemotherapeutic cytotoxicity
发明人：ROBERTS DAVID D; SOTO PANTOJA DAVID R
权利人:US HEALTH
摘要:Methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent, such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are provided. Example disclosed methods reduce cardiotoxicity. In one example, the methods include administering to a subject with cancer an effective amount of a CD47 antisense morpholino oligonucleotide and an anthracycline such as doxorubicin. Methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are also provided. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the DNA damaging agent.