2,2,2-三氯-1-(4-甲氧基苯基)乙醇置于sodium Hydroxide体系中,用 氯仿,水 用作溶剂,化学反应 0.5H,反应生成对甲氧基苦杏仁酸 参考文献:Decomposition Of Sodium Trichloroacetate In The Presence Of Quaternary Ammonium Under Microwave Irradiation: A Convenient One‐pot Synthesis Of α‐hydroxy Acids In Water 标题:Decomposition Of Sodium Trichloroacetate In The Presence Of Quaternary Ammonium Under Microwave Irradiation: A Convenient One‐pot Synthesis Of α‐hydroxy Acids In Water 摘要: Doi:10.1080/00397910600781091
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-8138272-B2 优先权日:2006-05-22 标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds 发明人:KONRADI ANDREI W; SMITH JENIFER L 权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC 摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.
专利号:US-7176282-B1 优先权日:1996-09-09 标 题 :Solid-phase peptide synthesis and agent for use in such synthesis 发明人:HOLM ARNE; LARSEN BJARNE DUE 权利人:ZEALAND PHARMA AS 摘要:The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents, which are useful in solid-phase peptide synthesis.
专利号:US-7348404-B2 优先权日:1996-09-09 标题 :Solid-phase peptide synthesis and agent for use in such synthesis 发明人:HOLM ARNE; LARSEN BJARNE DUE 权利人:ZEALAND PHARMA AS 摘要:The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents which are useful in solid-phase peptide synthesis.
专利号:CN-113355367-B 优先权日:2018-03-22 标题 :Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid
专利号:CN-108410831-B 优先权日:2018-03-22 标题:Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid
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合成参考文献
摘要:Parmeggiani, F.; Galman, J. L.; Montgomery, S. L.; Turner, N. J., Science of Synthesis, (2019) , 403. 摘要:J. J. Klingenberg, J. P. Thole and R. D. Lingg, J. Chem. Eng. Data 11, 94 (1966).