CAS: 944401-65-4; 5-Bromo-6-Fluoropyridin-2-Amine

该化合物是一种环环状有机化合物,其特点是以氨基和卤素功能组群取代了环状环状环状物;氨基生物组(NH2)在2位置的存在有助于其基本性和形成氢联结的潜力,使其成为有机合成和药用化学的一个有用的中间体;5位置的溴原子和6位置的氟虫原子,在6位置上引入了重要的电子密集性和急性效应,可影响该化合物的再活性和与生物目标的相互作用;该化合物的特点是在室内温度处于坚固状态,可能表现出极地溶剂中的中溶性;其独特的功能组群组合有助于多种应用,包括药物,农业化学品和作为合成更复杂的有机分子的一个建筑块;在处理时,应参考安全数据,因为卤化化合物可能构成具体的健康和环境风险.

英文名称5-Bromo-6-Fluoropyridin-2-Amine
中文名称5-溴-6-氟-2-吡啶胺
IUPAC名称5-bromo-6-fluoropyridin-2-amine
其它别名2-氨基-5-溴-6-氟吡啶; 5-Bromo-6-Fluoropyridin-2-Amine
CAS编号944401-65-4
MFCD编号:MFCD11848480
EINECS号:832-808-1
分子式:C5H4BrFN2分子量:191.0
产品CID: 1994922
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: SJXWFNBZBXZDCL-UHFFFAOYSA-N
InChI=1S/C5H4BrFN2/c6-3-1-2-4(8)9-5(3)7/h1-2H,(H2,8,9)
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数*

相似化合物

1232431-41-2 2857813-67-1 1207625-26-0

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xn

欧盟法规

C&L通报

上下游产品

CAS号1597-32-6 2-氨基-6-氟吡啶 | CAS号1054629-49-0 2-(2-氟-6-甲基氨基-吡... | CAS号944401-67-6 2-氨基-6-氟吡啶-5-硼酸频那醇酯

合成工艺路线路线简述

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Overnight,Rt
标题:Discovery And Evaluation Of 3-Quinoxalin Urea Derivatives As Potent,Selective,And Orally Available Atm Inhibitors Combined With Chemotherapy For The Treatment Of Cancer Via Goal-Oriented Molecule Generation And Virtual Screening
作者:Deng,Dexin; Yang,Yingxue; Zou,Yurong; Liu,Kongjun; Zhang,Chufeng; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2023 卷标:66(14) 页码:9495-9518]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 25 °C; 30 Min,15 °C; 2 H,25 °C1.2 Reagents: Water
标题:Heterocycles As Bcl-2 Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 2 H,5 - 15 °C; 3 H,Rt
标题:Condensed Heterocycles As Blc-2 Inhibitors In The Treatment Of Neoplastic,Autoimmune And Neurodegenerative Diseases
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 2 H,5 - 15 °C; 3 H,Rt
标题:Pyrrolopyridinooxazine Compounds And Related Compounds As Bcl-2 Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 30 Min,0 °C; 30 Min
标题:Preparation Of Fused Pyridinones And Related Compounds As Pim Kinase Inhibitors And Their Use In The Treatment Of Cancer
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 2 H,0 °C
标题:Preparation Of Substituted Imidazopyridines As Inhibitors Of Plasma Kallikrein And Uses Thereof
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; 0 °C; 1 H,Rt
标题:Heteroaromatic Compounds As Tyk2 Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 0 °C; 1 H,Rt
标题:Carbon-14 Radiosynthesis Of The Benzofuran Derivative And β-Amyloid Plaque Neuroimaging Positron Emission Tomography Radioligand Azd4694
作者:Johan,Sandell
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:2013 卷标:56(6) 页码:321-324]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 6 H,25 °C
标题:Pyrazolopyrrolopyridine Compounds And Related Compounds As Bcl-2 Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 30 Min,10 - 20 °C; 60 Min,Rt1.2 Reagents: Water
标题:Preparation Of 8-[6-[3-(Amino)Propoxy]-3-Pyridyl]-1-Isopropyl-Imidazo[4,5-C]Quinolin-2-One Derivatives As Selective Modulators Of Ataxia Telangiectasia Mutated (Atm) Kinase For The Treatment Of Cancer
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 30 Min,Rt -> 20 °C; 60 Min,Rt
标题:Imidazo[4,5-C]Quinolin-2-One Derivatives As Atm Kinase Inhibitors And Their Preparation And Use For The Treatment Of Cancer
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Rt; Overnight,Rt
标题:Preparation Of 6-Pyridine-3-Quinoxaline Urea Derivatives And Its Application
参考文献:China]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dimethylformamide; 0 °C; 18 H,20 °C1.2 Reagents: Water; 20 Min,20 °C
标题:Preparation Method Of 2-Fluoro-3,6-Dihydroxypyridine
参考文献:China]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 30 Min,0 °C; 2.5 H,0 °C
标题:Preparation Of Pyridine Compounds For The Treatment Of Pain
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 2 H,5 - 15 °C; 3 H,Rt
标题:Preparation Of Hot Melt Extruded Solid Dispersions Containing A Bcl-2 Inhibitor
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Rt; 3 H,Rt1.2 Solvents: Water; Rt
标题:Preparation Of 1H-Pyrrolo[2,3-B]Pyridine Derivatives And Related Compounds As Bcl-2 Inhibitors For Treating Neoplastic,Autoimmune Or Neurodegenerative Diseases
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 30 Min,0 °C; 30 Min,Rt
标题:Preparation Of Halo-Substituted Aminopyridine Compounds As Inhibitors Of The Hematopoietic Progenitor Kinase 1 (Hpk1)
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 2 H,25 °C
标题:Preparation Of Heteroaryl Compounds And Uses In Tau Imaging
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Cooled; 3 D,Rt
标题:Preparation Of Novel Tetrahydropyridopyrimidine Compounds,And Antiandrogens And Antitumor Agents Containing Them
参考文献:World Intellectual Property Organization]

1597-32-6 = 944401-65-4
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Overnight,Rt1.2 Solvents: Water; Rt
标题:Preparation Of Condensed Heterocyclic Derivatives As Bcl-2 Inhibitors For The Treatment Of Neoplastic Diseases
参考文献:World Intellectual Property Organization

📜2-氨基-6-氟吡啶置于n-溴代丁二酰亚胺(Nbs)体系中,用乙腈作为反应溶剂,化学反应 1.0H,以73%的收率获得产物5-溴-6-氟吡啶-2-胺
参考文献:Carbon-14 Radiosynthesis Of The Benzofuran Derivative Andβ-Amyloid Plaque Neuroimaging Positron Emission Tomography Radioligand Azd4694
标题:Carbon-14 Radiosynthesis Of The Benzofuran Derivative Andβ-Amyloid Plaque Neuroimaging Positron Emission Tomography Radioligand Azd4694
摘要:为了支持代谢物研究,从放射性标记的二氧化碳开始,经过 10 个放射合成步骤,用碳-14 标记了 β 淀粉样斑块神经影像正电子发射断层扫描放射性配体 Azd4694.在苯并呋喃杂环中标记的[14C]Azd4694的比活度为2.1 Gbq/mmol,放射化学纯度大于99%.所述合成方法是碳-14 标记取代苯并呋喃的通用方法.
DOI:10.1002/jlcr.3029

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2023119463-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to 1H-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

专利号:US-11731956-B2
优先权日:2018-10-22
标题:Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors

专利号:WO-2021133817-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:GUANGZHOU LUPENG PHARMACEUTICAL COMPANY LTD; NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).