CAS: 941294-58-2; Tert-Butyl 6-Bromonicotinate

该化合物是一个有机化合物,其特征是其丙烯环,这是一个六人组成的芳香异环,含有一个氮原子.在环的6个位置上存在一种溴替代成分,具有显著的再活动性,使其在各种化学合成中有用.由碳箱酸衍生的酯功能组有助于其有机溶剂溶解性及其进行水解或转性反应的潜力.三丁基基磷酰混合物组(1,1-二甲基乙基)可增强该化合物的成份,可影响其再活动性以及与其他分子的相互作用.该化合物由于其独特的结构特征,可能影响生物活动和物理特性,因此可能对医药化学和材料科学感兴趣.

结构式图片

相似化合物

6311-35-9 132334-98-6 263270-02-6

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MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号6311-35-9 6-溴烟酸 | CAS号865-47-4 叔丁醇钾 | CAS号36805-97-7 N,N-二甲基甲酰胺二叔丁基缩醛 | CAS号624-28-2 2,5-二溴吡啶 | CAS号24424-99-5 二碳酸二叔丁酯

合成工艺路线路线简述

  • 合成目标产物 T-Butyl 6-Bromo-3-Pyridinecarboxylate 主要起始原料 6-Bromonicotinic Acid And N,N-Dimethylformamide Di-Tert-Butyl Acetal
  • 24424-99-5 + 624-28-2 = 941294-58-2
    反应条件:1.1 Reagents: Chloro(1-Methylethyl)Magnesium Solvents: Tetrahydrofuran,Cyclopentyl Methyl Ether; -10 - 0 °C; 3 H,Heated1.2 Catalysts: Cuprous Iodide; Rt; 1 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3 - 4,0 - 10 °C
    标题:Green Preparation Of 6-Fluoronicotinic Acid
    参考文献:China]

    36805-97-7 + 6311-35-9 = 941294-58-2
    反应条件:1.1 Solvents: Toluene; Rt -> Reflux; 72 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water
    标题:Preparation Of Substituted Piperazine Derivatives For Use As Cb1 Antagonists
    参考文献:World Intellectual Property Organization]

    6311-35-9 + 865-47-4 = 941294-58-2
    反应条件:1.1 Reagents: Ethanedioyl Dibromide Catalysts: Dimethylformamide Solvents: Dichloromethane; 6 H,Reflux; Reflux -> Rt1.2 Solvents: Tetrahydrofuran; Rt -> 0 °C; 0 °C; 0 °C -> Rt; 2 H,Rt
    标题:Preparation Of Nicotinamide Derivatives As H-Pgds (Hematopoietic Prostaglandin D Synthase) Inhibitors
    参考文献:United States]

    36805-97-7 + 6311-35-9 = 941294-58-2
    反应条件:1.1 Solvents: Dimethylformamide,Toluene; 10 H,Reflux
    标题:Amide Compound Having Bet Proteolysis-Inducing Action,And Medicinal Application Thereof
    参考文献:World Intellectual Property Organization]

    = 941294-58-2 [标题:Reaction Conditions
    标题:Preparation Of Nicotinamide Derivatives For The Treatment Of Allergic And Respiratory Conditions
    参考文献:World Intellectual Property Organization]

    24424-99-5 + 6311-35-9 = 941294-58-2
    反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Tert-Butanol; Overnight,60 °C
    标题:Antibody-Drug Conjugate And Use Thereof
    参考文献:World Intellectual Property Organization]

    24424-99-5 + 6311-35-9 = 941294-58-2
    反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Tetrahydrofuran; Rt; 5 H,Reflux; Reflux -> Rt; 17 H,Reflux
    标题:Preparation Of 2-[3-(Pyridin-2-Yl)-4-(Quinolin-4-Yl)Pyrazol-1-Yl]Acetamide Derivatives As Inhibitors Of Transforming Growth Factor-Beta Receptor I/alk5
    参考文献:World Intellectual Property Organization]

    24424-99-5 + 624-28-2 = 941294-58-2
    反应条件:1.1 Reagents: Butyllithium,Butylmagnesium Chloride Solvents: Toluene,Tetrahydrofuran,Hexane; < -5 °C; 0.5 H,-10 °C1.2 Solvents: Toluene,Tetrahydrofuran; < -5 °C; 0.5 - 2 H,-10 °C1.3 Solvents: Toluene; < -5 °C; 2 - 3 H,-10 °C1.4 Reagents: Citric Acid Solvents: Water
    标题:Highly Selective And Efficient Conversion Of Aryl Bromides To T-Butyl Benzoates With Di-T-Butyl Dicarbonate
    作者:Li,Hongmei; Balsells,Jaume
    参考文献:Tetrahedron Letters 日期:2008 卷标:49(12) 页码:2034-2037]

    36805-97-7 + 6311-35-9 = 941294-58-2
    反应条件:1.1 Solvents: Toluene; Overnight,Rt -> Reflux; 72 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt
    标题:Substituted Piperazines As Cb1 Antagonists And Their Preparation
    参考文献:United States]

    36805-97-7 + 6311-35-9 = 941294-58-2
    反应条件:1.1 Solvents: Toluene; 72 H,Reflux
    标题:Preparation Of Substituted Piperazines As Cb1 Antagonists
    参考文献:World Intellectual Property Organization]

    6311-35-9 + 865-47-4 = 941294-58-2
    反应条件:1.1 Reagents: Ethanedioyl Dibromide Catalysts: Dimethylformamide Solvents: Dichloromethane; 6 H,Reflux; Reflux -> Rt1.2 Solvents: Tetrahydrofuran; 0 °C -> Rt; 2 H,Rt
    标题:Preparation Of Nicotinamide Derivatives For The Treatment Of Allergic And Respiratory Conditions
    参考文献:World Intellectual Property Organization
📜6-溴烟酸置于n,N-二甲基甲酰胺 草酰溴体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 6.0H,反应生成 6-溴烟酸叔丁酯
参考文献: Nicotinamide Derivatives[fr] Dérivés De Nicotinamide
标题: Nicotinamide Derivatives[fr] Dérivés De Nicotinamide
摘要:本发明涉及公式(I)的化合物及其药学上可接受的盐和溶剂化合物,其中取代基在此处定义,涉及含有这种化合物的组合物以及利用这种化合物治疗过敏和呼吸道疾病的用途.

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合成参考文献

合成方法参考DOI号:10.1016/j.tetlet.2007.12.134
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