CAS: 932033-57-3; 1,1'-(4,4'-Dimethoxy-[1,1'-Biphenyl]-3,3'-Diyl)Bis(Adamantane)

英文名称1,1'-(4,4'-Dimethoxy-[1,1'-Biphenyl]-3,3'-Diyl)Bis(Adamantane)
中文名称1,1'-(4,4'-二甲氧基[1,1'-联苯]-3,3'-二基)二金刚烷
IUPAC名称1,1'-(4,4'-dimethoxy-[1,1'-biphenyl]-3,3'-diyl)bis(adamantane)
其它别名2,2'-Bis-(1-Adamantyl)-4,4'-Dimethoxybiphenyl; 1,1'-(4,4'-Dimethoxy[1,1'-Biphenyl]-3,3'-Diyl)Bistricyclo[3.3.1.13,7]Decane; Adapalene Related Compound D; Adap-Imc; Adapalene Ep Impurity D; 4,4′-Dimethoxy-3,3′-Di(Adamant-1-yl)Biphenyl; Adapalene Related Compound D (25 Mg) (4,4'-Dimethoxy-3,3'-Di(Adamant-1-yl)Biphenyl); Adapalene Impurity 3
CAS编号932033-57-3
MFCD编号:MFCD26142856
EINECS号:809-498-1
FDA UNII编号:LV4PI5YV3S
分子式:C34H42O2分子量:482.71
产品CID: 1970444
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: SDMSVURKQNRAEU-UHFFFAOYSA-N
SDMSVURKQNRAEU-UHFFFAOYSA-N
计算化学: 氢键受体数2.0氢键供体数*可旋转键数5.0

物理性质

熔点285-289°C
密度1.147±0.06 g/cm3(预测)
PSA:18.46
LogP:8.3064
溶解性Chloroform (Slightly), Dichloromethane (Slightly)
外观形态白色至类白色
储存条件冰箱

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
危险品标志Xi
安全声明26
危险类别码36/38
WGK Germany3

欧盟法规

C&L通报

上下游产品

methyl 6-bromo-2-naphthoate 2-(1-adamantyl)-4-bromoanisole

合成工艺路线路线简述

2132-80-1 + 768-95-6 = 932033-57-3
反应条件:1.1 Catalysts: Sulfuric Acid Solvents: Acetic Acid,Methanol; Rt; 8 H,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 6.5
标题:Preparation Of 3,3'-Di(1-Adamantyl)-4,4'-Dimethoxy-1,1'-Biphenyl
参考文献:India]

104224-63-7 = 932033-57-3
反应条件:1.1 Reagents: Magnesium Solvents: 1,2-Dibromoethane,Tetrahydrofuran; 45 Min,45 °C1.2 Reagents: Zinc Chloride; 1 H,22 °C1.3 Catalysts: Palladium Diacetate; 24 H,Reflux1.4 Reagents: Hydrochloric Acid Solvents: Water
标题:Process For The Preparation Of Adapalene And Related Compounds
参考文献:World Intellectual Property Organization]

= 932033-57-3 [标题:Reaction Conditions
标题:Process For The Preparation Of Adapalene And Related Compounds
参考文献:United States]

= 932033-57-3 [标题:Reaction Conditions
标题:Isolation And Characterization Of Impurities In Adapalene
作者:Brenna,Elisabetta; Frigoli,Samuele; Fronza,Giovanni; Fuganti,Claudio; Sala,Federico
参考文献:Journal Of Pharmaceutical And Biomedical Analysis 日期:2007 卷标:43(3) 页码:1161-1163

📜2-(1-金刚烷基)-4-溴苯甲醚置于醋酸钯盐酸,二氯甲烷,水,甲醇体系中,用四氢呋喃作为反应溶剂,化学反应 24.0H,以to Yield 2.1 G Of 3,3'-Diadamantyl-4,4'-Dimethoxybiphenyl (Yield: 39.9%)的收率获得产物1,1'-(4,4'-二甲氧基[1,1'-联苯]-3,3'-二基)二金刚烷
参考文献:Process For The Preparation Of Adapalene And Related Compounds
标题:Process For The Preparation Of Adapalene And Related Compounds
摘要:该发明提供了一种改进的苯并萘衍生物制备过程,特别是高纯度阿达帕林的制造.该发明还包括一种通过定量比色测量所生产的阿达帕林的颜色来评估阿达帕林颜色的方法.