CAS: 932-90-1; Benzaldoxime

该化合物是有机化合物,其特点是有氧功能组和苯甲二酰胺,它看起来是无色的,是具有独特芳香气味的黄色黄色液体;苯丁二烯氧的分子配方是C8H9NO,表明含有碳,氢,氮和氧;该化合物以其通过各种试剂的反应形成衍生物的能力而闻名,使其在有机合成中有用;苯甲二烯氧在水中中可中溶,在乙醇和乙醇等有机溶剂中可溶性更大;主要用于合成药品,农用化学品和有机反应的中间体;此外,苯丁二烯氧化氮具有潜在的生物活动,这是医学化学研究的课题;与许多有机化合物一样,妥善处理和安全防范是其潜在刺激性所必不可少的.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号5470-11-1 盐酸羟胺 | CAS号100-52-7 苯甲醛 | CAS号100-51-6 苯甲醇 | CAS号1666-17-7 苯甲醛对甲苯磺酰腙 | CAS号100-46-9 苄胺 | CAS号2700-22-3 苯亚甲基丙二腈 | CAS号79-24-3 硝基乙烷 | CAS号29601-98-7 N-苄基羟胺盐酸盐 | CAS号104721-34-8 methyl 3-phenyl... | CAS号112129-04-1 N-chloro-1-phen... | CAS号105755-38-2 [[chloro(phenyl... | CAS号10264-14-9 N-苄基丁酰胺 | CAS号341001-38-5 [4-(2-氯-4-硝基苯基)... | CAS号3393-96-2 4'-硝基苯甲酰苯胺 | CAS号5425-44-5 2-苯基-1,3-二噻烷 | CAS号489-98-5 苦基胺 | CAS号100-52-7 苯甲醛 | CAS号54408-35-4 3-苯基异恶唑-5-基甲胺

合成工艺路线路线简述

  • 合成目标产物 Benzaldoxime 主要起始原料 Benzyl Alcohol
  • 100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Hydroxide,N,O-Dimethylhydroxylamine Hydrochloride Solvents: Methanol; Rt; 30 Min,Rt; 1 H,80 °C
    标题:Indazole Compound And Application Thereof For Preparing Ido Inhibitor Drug
    参考文献:China]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Hydroxyamine Hydrochloride,Ammonium Chloride Solvents: Ethanol,Water; 5 Min,Rt1.2 5 Min,Rt; 15 Min,Rt
    标题:An Unexpected Formation Of The Novel 7-Oxa-2-Azabicyclo[2.2.1]Hept-5-Ene Skeleton During The Reaction Of Furfurylamine With Maleimides And Their Bioprospection Using A Zebrafish Embryo Model
    作者:Puerto Galvis,Carlos E.; Kouznetsov,Vladimir V.
    参考文献:Organic & Biomolecular Chemistry 日期:2013 卷标:11(3) 页码:407-411]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydroxyamine Hydrochloride Solvents: Ethanol; 8 H,Rt
    标题:Preparation Of Thienopyridine-Containing Oxime Derivatives As Platelet Aggregation Inhibitors
    参考文献:China]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Hydroxyamine Hydrochloride Solvents: Ethanol,Pyridine
    标题:Highly Efficient And Catalytic Conversion Of Aldoximes To Nitriles
    作者:Yang,Soon Ha; Chang,Sukbok
    参考文献:Organic Letters 日期:2001 卷标:3(26) 页码:4209-4211]

    29601-98-7 = 932-90-1
    反应条件:1.1 Reagents: Triethylamine Solvents: (Trifluoromethyl)Benzene; 5 Min,Rt1.2 Reagents: Tempo; 0.5 H,Rt
    标题:Metal-Free 2,2,6,6-Tetramethylpiperidin-1-Yloxy Radical (Tempo) Catalyzed Aerobic Oxidation Of Hydroxylamines And Alkoxyamines To Oximes And Oxime Ethers
    作者:Wertz,Sebastian; Studer,Armido
    参考文献:Helvetica Chimica Acta 日期:2012 卷标:95(10) 页码:1758-1772]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydroxyamine Hydrochloride Solvents: Water; Neutralized1.2 1 H,Rt
    标题:Biologically Active Hydroxymoyl Chlorides As Antifungal Agents
    作者:Ismail,Tabasum; Shafi,Syed; Singh,Parvinder Pal; Qazi,Naveed Ahmed; Sawant,Sanghapal D.; Et Al
    参考文献:Indian Journal Of Chemistry 日期:2008 卷标:(5) 页码:740-747]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydroxyamine Hydrochloride Solvents: Water; Rt -> 0 °C; 20 Min,0 °C1.2 < 0 °C; 2 H,Cooled
    标题:Methods Of Using Igf1R And Abl Kinase Modulators For The Treatment Of Cancer,And Use With Other Therapies
    参考文献:World Intellectual Property Organization]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydroxyamine Hydrochloride Solvents: Water; Rt -> 0 °C; 20 Min,0 °C1.2 < 0 °C; 2 H,Cooled
    标题:Pyrimidine Derivative Kinase Modulators And Therapeutic Use
    参考文献:World Intellectual Property Organization]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydroxyamine Hydrochloride Solvents: Water; Neutralized,Rt1.2 Solvents: Ethanol; Rt; 2 H,Rt
    标题:Ru-Catalyzed [3 + 2] Cycloaddition Of Nitrile Oxides And Electron-Rich Alkynes With Reversed Regioselectivity
    作者:Feng,Qiang; Huang,Hai; Sun,Jianwei
    参考文献:Organic Letters 日期:2021 卷标:23(7) 页码:2431-2436]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Acetate,Hydroxyamine Hydrochloride Solvents: Methanol,Water; 2 H,Rt
    标题:The Bioorthogonal Isonitrile-Chlorooxime Ligation
    作者:Schafer,Rebecca J. B.; Monaco,Mattia R.; Li,Mao; Tirla,Alina; Rivera-Fuentes,Pablo; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2019 卷标:141(47) 页码:18644-18648]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Carbonate,Hydroxyamine Hydrochloride Solvents: Ethanol,Water; 0 °C; 2 H,Rt
    标题:Isoxazolyl-Carbonyloxy Azabicyclo[3.2.1]Octanyl Compounds As Fxr Activators And Their Preparation
    参考文献:World Intellectual Property Organization]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Acetate,Hydroxylamine-O-Sulfonic Acid Solvents: Ethanol,Water; 30 Min,Rt1.2 30 Min,Rt -> Reflux
    标题:Iron-Catalyzed Asymmetric Nitro-Mannich Reaction
    作者:Dudek,Agata; Mlynarski,Jacek
    参考文献:Journal Of Organic Chemistry 日期:2017 卷标:82(20) 页码:11218-11224]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Carbonate,Hydroxyamine Hydrochloride Solvents: Methanol,Water; Rt; Overnight,Rt
    标题:Boronic Acid Mediated Coupling Of Catechols And N-Hydroxylamines: A Bioorthogonal Reaction To Label Peptides
    作者:Meadows,Margaret K.; Roesner,Emily K.; Lynch,Vincent M.; James,Tony D.; Anslyn,Eric V.
    参考文献:Organic Letters 日期:2017 卷标:19(12) 页码:3179-3182]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydroxyamine Hydrochloride Solvents: Ethanol,Water; Neutralized1.2 20 °C; 1 H,Rt
    标题:Synthesis And Characterization Of Para-Substituted N,N'-Dihydroxybenzamidines And Their Derivatives As Model Compounds For A Class Of Prodrugs
    作者:Schwarz,Laura; Girreser,Ulrich; Clement,Bernd
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(9) 页码:1961-1975]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Hydroxyamine Hydrochloride; 10 Min,45 - 50 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt
    标题:Kneading Ball-Milling And Stoichiometric Melts For The Quantitative Derivatization Of Carbonyl Compounds With Gas-Solid Recovery
    作者:Mokhtari,Javad; Naimi-Jamal,Mohammad R.; Hamzeali,Hamideh; Dekamin,Mohammad G.; Kaupp,Gerd
    参考文献:Chemsuschem 日期:2009 卷标:2(3) 页码:248-254]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Carbonate,Hydroxyamine Hydrochloride Solvents: Ethanol,Water; 1 H,60 °C
    标题:Synthesis Of Piperazinylalkylisoxazoline Analogs And Their Binding Affinities For Dopamine Receptor Subtypes
    作者:Jung,Ji Young; Jung,Sun Ho; Koh,Hun Yeong; Pae,Ae Nim; Park,Woo-Kyu; Et Al
    参考文献:Bulletin Of The Korean Chemical Society 日期:2006 卷标:27(11) 页码:1861-1864]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Acetone,Oxime Solvents: Acetic Acid
    标题:New Oximation Method For Aldehydes And Ketones
    作者:Juskowiak,Michal; Krzyzanowski,Piotr
    参考文献:Journal Fuer Praktische Chemie (Leipzig) 日期:1989 卷标:331(5) 页码:870-2]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydroxyamine Hydrochloride Solvents: Water; Neutralized1.2 1 H,Rt
    标题:Synthesis And Immunopotentiating Activity Of Novel Isoxazoline Functionalized Coumarins
    作者:Ismail,Tabasum; Shafi,Syed; Singh,Swarn; Sidiq,Tabasum; Khajuria,Anamika; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2016 卷标:123 页码:90-104]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Ammonia,Hydrogen Peroxide Catalysts: Lanthanate(11-),Bis[eicosa-μ-Oxoundecaoxo[μ11-[phosphato(3-)-Ko:Ko:Ko:Ko′:Ko′:K... Solvents: 1-Butanol,Water; 6 H,Rt
    标题:Highly Selective And Efficient Lewis Acid-Base Catalysts Based On Lanthanide-Containing Polyoxometalates For Oximation Of Aldehydes And Ketones
    作者:Zhao,Shen; Huang,Lujiang; Song,Yu-Fei
    参考文献:European Journal Of Inorganic Chemistry 日期:2013 卷标:2013(10-11) 页码:1659-1663]

    100-52-7 = 932-90-1
    反应条件:1.1 Reagents: Sodium Carbonate,Hydroxyamine Hydrochloride Solvents: Ethanol,Water; 1 H,0 °C
    标题:Preparation Of Carbamoylisoxazoles As Caspase Inhibitors
    参考文献:World Intellectual Property Organization
📜α-Nitroso-Toluol 以 氘代二甲亚砜 作为反应溶剂,化学反应生成 苯甲醛肟
参考文献:关于邻碘氧苯甲酸(ibx)氧化羟胺
标题:关于邻碘氧苯甲酸(ibx)氧化羟胺
摘要:作为合成中碘的特别战略现代战略的一部分出版 抽象的 邻碘氧苯甲酸(ibx)被证实是氧化羟胺的有力工具.该合成路线被证明是有效和用户友好的,并且被用于各种碳水化合物衍生的n,N-二取代羟胺(环状,无环和官能化的),从而以非常好的产率和区域选择性提供了相应的硝酮.n-单取代的羟胺根据反应条件显示出有趣的发散行为.据报道,Ibx在二甲基亚砜中于45oc氧化可提供肟,而在室温下于二氯甲烷中的氧化则可有效提供相应的亚硝基二聚体. 邻碘氧苯甲酸(ibx)被证实是氧化羟胺的有力工具.该合成路线被证明是有效和用户友好的,并且被用于各种碳水化合物衍生的n,N-二取代羟胺(环状,无环和官能化的),从而以非常好的产率和区域选择性提供了相应的硝酮.n-单取代的羟胺根据反应条件显示出有趣的发散行为.据报道,Ibx在二甲基亚砜中于45oc氧化可提供肟,而在室温下于二氯甲烷中的氧化则可有效提供相应的亚硝基二聚体.
DOI:10.1055/s-0036-1588457

海关参考信息

专利信息


专利号:US-5072056-A
优先权日:1989-09-26
标 题:Synthesis of 2-phenyl-1,3-propanediol
发明人：STIEFEL FRANK J
权利人:CARTER WALLACE
摘要:A novel method of preparing 2-phenyl substituted-1, 3-propanediols, useful intermediates in the synthesis of pharmaceutical preparations is disclosed.

专利号:WO-2023198025-A1
优先权日:2022-04-11
标题:Synthesis method and synthesis device for organic nitrogen-containing compound
发明人：LI GUANGQIN; Liao Peisen; XIAN JIAHUI; LI SUISHENG; ZHANG YAWEI
权利人:UNIV SUN YAT SEN
摘要:The present invention relates to the field of organic synthesis, specifically to a synthesis method and synthesis device for an organic nitrogen-containing compound. Provided in the present invention is a synthesis method for an organic nitrogen-containing compound. In the method provided in the present invention, a porous carbon material is used as a catalyst, organic nitrogen-containing compounds such as an oxime, an amine, a nitrile and an amino acid are synthesized by means of an electro-catalysis method, byproducts are unlikely to generate, and the method is safe and environmentally friendly. Experiments show that organic nitrogen-containing compounds such as an amino acid, an oxime, an amine and a nitrile are successfully synthesized by using the method of the present invention, and the method has good Faraday efficiency and yield. In the present application, the synthesis of the above organic nitrogen-containing compounds can be realized by using nitrogen oxide waste gas or waste water as a raw material; and by converting the nitrogen oxide waste gas or waste water, the utilization of waste is realized, and the benefits are maximized. Further provided in the present invention is a synthesis device for an organic nitrogen-containing compound, which device is used for solving the defects of high energy consumption, long consumption time, and complex product separation and purification of existing synthesis methods.

专利号:US-6225329-B1
优先权日:1998-03-12
标 题 :Modulators of protein tyrosine phosphatases (PTPases)
发明人：RICHTER LUTZ STEFAN; ANDERSEN HENRIK SUNE; VAGNER JOSEF; JEPPESEN CLAUS BEKKER; MOELLER NIELS PETER HUNDAHL; BRANNER SVEN; SU JING; BAKIR FARID; JUDGE LUKE MILBURN
权利人:NOVO NORDISK AS
摘要:The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like, n wherein A, R 1 , R 2 , R 3 , R 4 , R 16 and R 17 are as defined in the specification. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:WO-9946236-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人：RICHTER LUTZ STEFAN; ANDERSEN HENRIK SUNE; VAGNER JOSEF; JEPPESEN CLAUS BEKKER; MOELLER NIELS PETER HUNDAHL; BRANNER SVEN; SU JING; BAKIR FARID; JUDGE LUKE MILBURN
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:EP-1062199-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人：RICHTER LUTZ STEFAN; ANDERSEN HENRIK SUNE; VAGNER JOSEF; JEPPESEN CLAUS BEKKER; MOLLER NIELS PETER HUNDAHL; BRANNER SVEN; SU JING; BAKIR FARID; JUDGE LUKE MILBURN
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:WO-8911473-A1
优先权日:1988-05-27
标 题:Process for the synthesis of o-substituted oxime compounds
发明人：CHEMPOLIL THOMAS MATHEW
权利人:ALLIED SIGNAL INC
摘要:A novel process for the production of O-substituted oximes is disclosed. The process involves reacting an oxime with an alkali-metal hydroxide optionally in a solvent which forms an azeotrope with water to form a mixture of the alkali metal salt of the oxime and water, removing all or a portion of the water by distilling the mixture azeotropically and reacting the distilled mixture with an alpha halo carboxylic acid.

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主要参考文献


1: Sun GS, Xu X, Jin SH, Lin L, Zhang JJ. Ovicidal and Insecticidal Activities of Pyriproxyfen Derivatives with an Oxime Ester Group. Molecules. 2017 Jun 8;22(6). pii: E958. doi: 10.3390/molecules22060958. doi: 10.1039/c7cc00237h. doi: 10.1021/jf500461a. Epub 2014 Mar 27. doi: 10.1107/S1600536812010732. Epub 2012 Mar 17.
5: Zonouzi A, Mirzazadeh R, Ng SW. (E)-2-Bromo-benzaldehyde oxime. Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2338. doi: 10.1107/S1600536811032211. Epub 2011 Aug 17.
6: Carberry P, Carpenter AP, Kung HF. Fluoride-18 radiolabeling of peptides bearing an aminooxy functional group to a prosthetic ligand via an oxime bond. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6992-5. doi: 10.1016/j.bmcl.2011.09.124. Epub 2011 Oct 5.

合成参考文献


参考文献:10.1007/bf02815202
摘要:Joseph JA, Denisova N, Villalobos-Molina R, Erat S, Strain J. Oxidative stress and age-related neuronal deficits. Molecular and Chemical Neuropathology. 1996 May;28(1-3):35–40. doi: 10.1007/bf02815202.
参考文献:10.1007/128_2011_155
摘要:Aakeröy CB, Epa K. Controlling supramolecular assembly using electronic effects. Top Curr Chem. 2014;351():125–47. doi: 10.1007/128_2011_155.
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