CAS: 86123-11-7; Fmoc-D-Trp-Oh

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Fmoc-D-色氨酸置于chiral Column Based On 3,5-Dimethylphenylcarbamoylated β-Cyclodextrin Combining Cinchona Alkaloid Immobilized On Silica Gel体系中,用 甲醇,甲酸,三乙胺,乙腈 作为反应溶剂,化学反应生成 Fmoc-L-色氨酸,Fmoc-D-色氨酸
参考文献:基于3,5-二甲基苯基氨基甲酰基化的β-环糊精结合金鸡纳生物碱部分的新型手性固定相.
标题:基于3,5-二甲基苯基氨基甲酰基化的β-环糊精结合金鸡纳生物碱部分的新型手性固定相.
摘要:合成了基于3,5-二甲基苯基氨基甲酰基化的β-环糊精连接奎宁(qn)或奎尼丁(qd)部分的新型手性选择剂,并将其固定在硅胶上.通过与3,5-二甲基苯基氨基甲酰基化的β-环糊精(β-Cd)手性固定相(csp)和9-O-(叔)进行比较,研究了它们的色谱性能.-丁基氨基甲酰基)-基于qn的csp(qn-Ax).在csp上评估了fmoc保护的氨基酸,手性药物cloprostenol(已成功用于兽医学)和中性手性分析物,结果表明,这种新型csp既具有cd基csp的对映体分离能力,又具有qn /与基于β-Cd的csp或基于qn / Qd的csp相比,基于qd的csp具有更广泛的应用范围.发现qn / Qd部分在fmoc-氨基酸的整个对映体分离过程中起主导作用,并伴随有β-Cd部分的协同作用,从而导致基于β-Cd-Qn的csp和β的不同对映体分离基于cd-Qd的csp.此外,
DOI:10.1002/chir.23237

专利信息

专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.

专利号:US-9388212-B2
优先权日:2013-02-21
标 题:Solid phase peptide synthesis via side chain attachment
发明人：BARLOS KLEOMENIS K
权利人:CHEMICAL & BIOPHARMACEUTICAL LAB OF PATRAS S A
摘要:The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:WO-2023030278-A1
优先权日:2021-08-30
标题:Full-liquid-phase synthesis method for reelin drug
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN SANTAI PHARMACEUTICAL CO LTD
摘要:Provided is a full-liquid-phase synthesis method for a reelin drug, belonging to the technical field of medicine synthesis. A liquid-phase method is used to synthesize 'Trp-Ser-Tyr' fragments, 'R5-Leu' fragments, 'PYR-His' fragments, and 'Arg-Pro-Gly-NH2' respectively, wherein R=D-Trp, Gly or D-2-NAL; and a reelin drug is synthesized in a '3+2+2+3' fragment condensation manner. The method has the characteristics of low reaction costs, non use of toxic reagents, a high product yield, and high purity, and is environmentally friendly, and is thus suitable for large-scale production.

专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries