CAS: 83242-95-9; N,N-Diisobutyl-2-(Octyl(Phenyl)Phosphoryl)Acetamide

📜三苯基氧化膦置于sodium体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 35.0H,反应生成 正辛基苯基-N,N-二异丁胺基甲酰基甲基氧化膦
参考文献:一种辛基(苯基)-N,N-二异丁基氨基甲酰甲基氧化膦的制备方法
标题:一种辛基(苯基)-N,N-二异丁基氨基甲酰甲基氧化膦的制备方法
摘要:本发明公开了一种辛基(苯基)‑n,N‑二异丁基氨基甲酰甲基氧化膦的制备方法,属于有机合成技术领域.本发明以工业副产废料三苯基氧化膦ph3P(0)为原料,与金属钠反应切断一分子p‑ph键,再加入1‑卤辛烷继续反应,此时产物继续与金属钠反应切断另一分子p‑ph键,最后与2‑氯‑n,N‑双(2‑甲基丙基)乙酰胺反应,得到目标产物辛基(苯基)‑n,N‑二异丁基氨基甲酰甲基氧化膦.本发明采取的原料廉价易得,在金属钠的作用下,经两次p‑ph键切断,分别替换上辛基,N,N‑二异丁基氨基甲酰甲基,通过一锅法进行反应直接获得目标产物,工艺成本低,反应条件温和,反应高效,易操作,不产生氯化铝废料,有利于经济成本和环境保护,适合工业化放大生产.#imgabs0#

专利信息

专利号:US-6909010-B2
优先权日:2001-04-11
标题:Facile synthesis of symmetric esters of alkylenebisphosphonic acids
发明人：HERLINGER ALBERT W; STEPINSKI DOMINIQUE C
权利人:UNIV LOYOLA CHICAGO
摘要:A facile synthesis of symmetric esters of C 1 -C 10 alkylenebisphopsphonic acids is disclosed in which a C 1 -C 10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazole and a base in an aprotic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.

专利号:US-2003060648-A1
优先权日:2001-04-11
标题 :Facile synthesis of symmetric esters of alkylenebisphosphonic acids

专利号:US-2005234257-A1
优先权日:2001-04-11
标 题 :Facile synthesis of symmetric esters of alkylenebisphosphonic acids

专利号:WO-02085918-A1
优先权日:2001-04-11
标 题:A facile synthesis of symmetric esters of alkylenebisphosphonic acids

专利号:US-11498051-B2
优先权日:2017-07-06
标题:Method for preparing a monolithic stationary phase, associated method for producing a chromatography column and associated separation method
发明人：LOSNO MARION; MARIET CLARISSE
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to a method for preparing a monolithic stationary phase in the interior volume of a chromatography column made of thermoplastic polymer. This method comprises the following steps: (i) modifying the inner wall of the chromatography column by implementing the following steps: (a) preparing a polymerizable anchoring composition comprising at least one particular methacrylate monomer, one or more solvents and 2,2-dimethoxy-2-phenylacetophenone, (b) depositing, on the inner wall of the column, the polymerizable anchoring composition prepared in step (a), and (c) polymerizing the polymerizable anchoring composition by irradiation with ultraviolet radiation; (ii) introducing, into the interior volume of the column, a polymerizable monolith synthesis composition comprising first and second particular (meth)acrylate monomers, one or more pore-forming agents and a free-radical polymerization initiator; and (iii) polymerizing the polymerizable monolith synthesis composition. The invention also relates to a method for producing a chromatography column comprising such a monolithic stationary phase and to a chromatographic separation method using such a column.