CAS: 82830-49-7; 2-Fluoro-1,4-Dimethoxybenzene

上下游产品

2-fluoro-1,4-benzoquinone dimethyl sulfate 1,4-dimethoxybezene N-fluorobis(benzenesulfon)imide 2,5-dimethoxy-4-fluorobenzaldehyde 2-fluoro-3,6-dimethoxybenzaldehyde tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol[3-but-3-enyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol[3-but-3-enyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

对苯二甲醚置于正丁基锂,N-氟代双苯磺酰胺体系中,化学反应生成 1,4-二甲氧基-2-氟苯
参考文献:苯乙基噻唑基硫脲(pett)化合物是一类新的hiv-1逆转录酶抑制剂.2. Pett类似物的合成和进一步的构效关系研究.
标题:苯乙基噻唑基硫脲(pett)化合物是一类新的hiv-1逆转录酶抑制剂.2. Pett类似物的合成和进一步的构效关系研究.
摘要:苯乙基噻唑基硫脲(pett)衍生物已被鉴定为hiv-1 Rt的一系列新的非核苷抑制剂.此类化合物的构效关系研究确定了n-[2-(2-吡啶基)乙基]-N'-[2-(5-溴吡啶基)]-硫脲盐酸盐(卓维定; Ly300046.Hcl)作为高效的抗hiv-1药物.trovirdine目前正处于一期临床试验中,有望用于治疗aids.正在扩展这些结构-活性关系研究以鉴定该系列中具有改进性能的其他化合物.这里描述了这项工作的一部分.研究了各种取代或未取代的杂芳族环取代pett化合物的两个芳族部分.此外,还研究了苯环上多重取代的影响.在细胞培养测定中,对野生型和构建的hiv-1 Rt突变体以及野生型hiv-1及其衍生的突变病毒ile100和cys181测定了抗病毒活性.在双突变病毒hiv-1(ile 100 / Asn103)和hiv-1(ile100 / Cys181)上确定了一些选定的化合物.合成
DOI:10.1021/jm950639R

专利信息

专利号:US-7138426-B2
优先权日:2002-04-24
标 题:Estrogen receptor modulators
发明人：DININNO FRANK P; BLIZZARD TIMOTHY ALLEN; MORGAN II JERRY DWAIN
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

专利号:US-2003225132-A1
优先权日:2002-04-11
标题:Estrogen receptor modulators
发明人：DININNO FRANK P; HAMMOND MILTON LLOYD
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

专利号:US-6750213-B2
优先权日:2000-10-19
标题:Estrogen receptor modulators
发明人：DININNO FRANK P; WU JANE Y; KIM SEONGKON; CHEN HELEN Y
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.