CAS: 74472-52-9; 2,2',3,4,4',5,6,6'-Heptachlorobiphenyl
该化合物是多氯联苯(PCB)家族的成员,其特点是结构复杂,由两只双联苯环组成,8个氯原子在不同位置被替换,众所周知,该化合物具有疏水性,低挥发性,高热稳定性,因此耐受环境退化的影响.OC-8通常存在于工业应用中,特别是电气设备和热传输液,因其绝缘性很强,因此引起人们对生物累积性以及可能对野生动物和人类健康产生有毒影响的关切.包括OC-8在内的多氯联苯与各种有害健康影响有关,包括内分泌干扰和致癌性.监管措施已导致许多国家减少并最终禁用多氯联苯,同时强调监测和管理此类物质以减轻其环境影响的重要性.
- 英文名称2,2',3,4,4',5,6,6'-Heptachlorobiphenyl
- 中文名称八氯联苯
- IUPAC名称1,2,3,4,5-pentachloro-6-(2,4,6-trichlorophenyl)benzene
- 其它别名2,2',3,4,4',5,6,6'-°Ctachlorobiphenyl; 2,3,4,5,6,2',4',6'-°Ctachlorobiphenyl
- CAS编号74472-52-9
- MFCD编号:MFCD00152687
- FDA UNII编号:LJJ2UNV2AD
- 分子式:C12H2Cl8分子量:429.77
- 产品CID: 1734802
- 产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
pentachlorobenzene 2,4,6-trichloroaniline合成工艺路线路线简述
- 合成目标产物 2,2',3,4,4',5,6,6'-Octachlorobiphenyl 主要起始原料 Pentachlorobenzene And 2,4,6-Trichloroaniline
- (文献来源)合成步骤主要原料 Pentachlorobenzene 和 2,4,6-Trichloroaniline
📜五氯苯,2,4,6-三氯苯胺置于亚硝酸异戊酯体系中,化学反应生成 八氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
摘要:T6: World Health Organization (1993). Environ Health Criteria 140: Polychlorniated Biphenyls and Terphenyls.
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