CAS: 7017-48-3; 2-(5-Bromo-2-Methoxyphenyl)Acetic Acid

上下游产品

CAS号93-25-4 2-甲氧基苯乙酸 | CAS号863562-62-3 (5-溴-2-甲氧基苯基)-乙酸乙酯 | CAS号7062-40-0 2-(5-溴-2-甲氧基苯基)乙氰 | CAS号7017-52-9 4-溴-2-氯甲基-1-甲氧基苯 | CAS号80866-82-6 5-溴-2-甲氧基苯甲醇 | CAS号2316-64-5 5-溴-2-羟基苯甲醇 | CAS号294860-58-5 2-(5-溴-2-甲氧基苯基)乙酸甲酯

📜5-溴-2-甲氧基苯乙腈置于氢氧化钾体系中,化学反应生成 5-溴-2-甲氧基苯乙酸
参考文献:Vejdelek,Z.J. Et Al.,Collection Of Czechoslovak Chemical Communications,1964,Vol. 29,P. 776-794
标题:Vejdelek,Z.J. Et Al.,Collection Of Czechoslovak Chemical Communications,1964,Vol. 29,P. 776-794

专利信息

专利号:US-10266503-B1
优先权日:2016-05-24
标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins
发明人：WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN
权利人:UNIV ILLINOIS
摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.