CAS: 701-45-1; 3-Bromo-4-Fluoronitrobenzene

上下游产品

CAS号1072-85-1 1-溴-2-氟苯 | CAS号350-46-9 对氟硝基苯 | CAS号7439-89-6 铁粉 | CAS号425378-68-3 2-(2-氟-5-硝基苯基)-... | CAS号191602-42-3 2-溴-1-异丙氧基-4-硝基苯 | CAS号79110-05-7 2-氟-5-硝基苯基乙酮 | CAS号64230-23-5 N,N-二甲基-2-溴-4-硝基苯胺 | CAS号656-64-4 3-溴-4-氟苯胺 | CAS号77123-60-5 3-乙炔基-4-氟苯胺 | CAS号1009-75-2 3'-溴-4'-氟乙酰苯胺 | CAS号154716-47-9 4-fluoro-3-pyri... | CAS号320337-13-1 2-bromo-1-[(3-f... | CAS号960309-85-7 3-溴-4-叔丁氧基硝基苯

对氟硝基苯置于溴,铁粉体系中,化学反应 16.0H,以67%的收率获得产物3-溴-4-氟硝基苯
参考文献:由π缺陷的1,2-二卤代芳烃和双烯键烯胺合成2-氨基吲哚和6-氨基吡咯并[3,2-D]嘧啶的新方法
标题:由π缺陷的1,2-二卤代芳烃和双烯键烯胺合成2-氨基吲哚和6-氨基吡咯并[3,2-D]嘧啶的新方法
摘要:摘要 提出了一种通过双烯二胺和π-缺陷的1,2-二卤代芳烃合成稠合的2-氨基吡咯的有效方法.两步法包括用二烯二胺c-亲核中心芳族亲核取代二卤代芳烃的活化卤素,然后进行cu催化的分子内n-芳基化.该方法允许在温和条件下以中等和非常好收率获得各种2-氨基-6-硝基吲哚和6-氨基吡咯并[3,2-D]嘧啶(包括n-单-和n,N-二取代). 提出了一种通过双烯二胺和π-缺陷的1,2-二卤代芳烃合成稠合的2-氨基吡咯的有效方法.两步法包括用二烯二胺c-亲核中心芳族亲核取代二卤代芳烃的活化卤素,然后进行cu催化的分子内n-芳基化.该方法允许在温和条件下以中等和非常好收率获得各种2-氨基-6-硝基吲哚和6-氨基吡咯并[3,2-D]嘧啶(包括n-单-和n,N-二取代).
DOI:10.1055/s-0035-1561645

专利信息

专利号:US-7511150-B2
优先权日:2006-07-06
标 题:Synthesis of heterocyclic compounds
发明人：ARALDI GIAN-LUCA; RONSHEIM MELANIE; DIEP NHUT; ZHOU SHAO HONG
权利人:FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.

专利号:US-2008009632-A1
优先权日:2006-07-06
标 题:Synthesis of heterocyclic compounds

专利号:US-4446075-A
优先权日:1980-02-22
标 题:Substituted bromofluorobenzene derivatives and process for its manufacture
发明人：EIGLMEIER KURT; KNIEPS REINHARD
权利人:RIEDEL DE HAEN AG
摘要:Substituted bromofluorobenzene, wherein the fluorine is in para-position and the bromine in meta-position to another substituent, is prepared by direct bromination of the corresponding fluorobenzene derivative. Bromination is advantageously carried out in the presence of a catalyst, preferably a metal or metal salt. The elementary bromine is used in an amount of 0.9 to 1.3 mols per mol of fluorobenzene derivative and the reaction temperature is between 20° and 200° C. The bromofluorobenzene derivatives are suitable for the synthesis of medicaments and plant protective agents.

专利号:US-2009143593-A1
优先权日:2006-07-06
标 题:Synthesis of heterocyclic compounds

专利号:US-7563900-B2
优先权日:2004-10-13
标 题:Process for the preparation N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methane sulfonamido-dibenzo[b,d]furan-1-carboxamide
发明人：GOPALAN BALASUBRAMANIAN; GHARAT LAXMIKANT A; CHANDRASEKHAR BATCHU; PILLAI BIJUKUMAR G
权利人:GLENMARK PHARMACEUTICALS SA
摘要:The present invention relates to a method of preparing N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof, such as its sodium salt, and novel intermediate compounds useful in the synthesis of the aforementioned compound.

专利号:US-2009192315-A1
优先权日:2006-07-06
标题 :Synthesis of heterocyclic compounds