CAS: 64190-70-1; Phe-Met-Arg-Phe Amide

上下游产品

L-Phenylalanine amide H-Phe-Met-Arg-OH 2B°C-Phe-Met-Arg(Mts)-Phe-NH2 γ-nitro-L-arginyl-L-phenylalaninamideN-benzoxycarbonyl-L-phenylalanyl-L-methionyl-N-γ-nitro-L-arginyl-L-phenylalaninamide

专利信息

专利号:US-4152322-A
优先权日:1978-04-28
标 题 :Process for selective reduction of nitroarginyl peptides with titanium (iii)
发明人：FREIDINGER ROGER M
权利人:MERCK & CO INC
摘要:Nitroarginyl peptides are selectively reduced to the corresponding arginyl peptides by titanium (III). The nitro protecting group which is labile toward nucleophilic reagents is retained through part of a synthesis and selectively removed prior to treatment with nucleophiles such as hydrazine and ammonia. The selectivity of titanium (III) for removal of the nitro functionality increases the flexibility of this protecting group in the synthesis of arginyl peptides. The present novel process is useful in the synthesis of medicinal peptides such as molluscan cardiac stimulant H-Phe-Met-Arg-Phe-NH 2 .

专利号:WO-9640890-A1
优先权日:1995-06-07
标题 :Non-naturally occurring targeted lipolytic compounds: synthesis, demonstration of potency, and practical and therapeutic applications