专利号:US-12312325-B2 优先权日:2022-03-01 标 题:Methods and compounds useful in the synthesis of an AAK1 inhibitor 发明人:CHEN TAO; WU WENXUE; YAN JUN; ZENG XIANGLU; ZHAO MATTHEW MANGZHU 权利人:LEXICON PHARMACEUTICALS INC 摘要:Methods for the synthesis of (S)-1-((2′,6-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine and salts thereof are disclosed, as well as compounds useful therein.
专利号:WO-2025083208-A1 优先权日:2023-10-19 标题 :Synthesis of morpholine derivatives and compounds therefore 发明人:BUESCHLEB MARTIN; BEAUFILS FLORENT; PROUDFOOT JOHN 权利人:BOEHRINGER INGELHEIM INT 摘要:The present invention relates to a synthesis method for morpholine derivatives, including a ring-formation out of a 1,2-amino alcohol and a compound of formula (I) whereby LG is a nucleophilic leaving group and R1 to R7 are as herein defined.
专利号:US-12077552-B2 优先权日:2021-09-14 标 题:Synthesis of fluoroalkyl tin precursors 发明人:KUIPER DAVID 权利人:ENTEGRIS INC 摘要:The invention provides certain fluorinated alkyl tin compounds which are believed to be useful in the vapor deposition of tin-containing films onto the surface of microelectronic device substrates. Also provided are processes for the preparation of the precursor compounds and processes for the use of such compounds in the deposition of tin-containing films onto microelectronic device substrates.
专利号:US-2023098280-A1 优先权日:2021-09-14 标 题:Synthesis of fluoroalkyl tin precursors
专利号:US-9351974-B2 优先权日:2011-11-10 标题 :Substituted pteridinones for the treatment of cancer 发明人:JIN MEIZHONG; KADALBAJOO MRIDULA; LI AN-HU; MULVIHILL MARK J; SIU KAM W; STEINIG ARNO G; WANG JING 权利人:OSI PHARMACEUTICALS LLC 摘要:Compounds of Formula I, as shown below and defined herein: n npharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven or mediated at least in part by RSK. This Abstract is not limiting of the invention.
专利号:EP-4402147-A1 优先权日:2021-09-14 标题:Synthesis of fluoroalkyl tin precursors
[参考文献]: Alexandre L'Heureux, Et Al. Aminodifluorosulfinium Salts: Selective Fluorination Reagents With Enhanced Thermal Stability And Ease Of Handling. J Org Chem. 2010 May 21;75(10):3401-11. [参考文献]: Francis Beaulieu, Et Al. Aminodifluorosulfinium Tetrafluoroborate Salts As Stable And Crystalline Deoxofluorinating Reagents. Org Lett. 2009 Nov 5;11(21):5050-3.
合成参考文献
摘要:Ouellet-Du Berger, M.-R.; Paquin, J.-F., Science of Synthesis: Knowledge Updates, (2023) 2, 279. 摘要:de Figueiredo, R. M., Science of Synthesis: Knowledge Updates, (2024) 2, 264. 摘要:Cheng, Q.; Shen, X., Science of Synthesis: Knowledge Updates, (2025) 2. 摘要:Lai, J.; Thomson, B. J.; Sammis, G. M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 26. 摘要:Arimitsu, S.; Cahard, D., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 56.