CAS: 602-41-5; N-((S)-1,2-Dimethoxy-10-(Methylthio)-9-Oxo-3-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-5,6,7,9-Tetrahydrobenzo[a]Heptalen-7-yl)Acetamide

上下游产品

CAS号163956-01-2 3-demethyl-3-(2... | CAS号87424-25-7 3-demethylthi°C... | CAS号477-29-2 秋水仙碱苷 | CAS号5188-07-8 甲硫醇钠 | CAS号572-09-8 2,3,4,6-四乙酰氧基-a... | CAS号87424-25-7 3-demethylthi°C...

2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖酰氟置于sodium Hydroxide,三氟化硼乙醚,四甲基胍体系中,用 乙醇,乙腈 作为反应溶剂,化学反应 5.5H,反应生成 硫秋水仙苷
参考文献:新型3-O-糖基-3-脱甲基硫代秋水仙碱作为甘氨酸和γ-氨基丁酸受体的配体.
标题:新型3-O-糖基-3-脱甲基硫代秋水仙碱作为甘氨酸和γ-氨基丁酸受体的配体.
摘要:制备了含有天然和非天然糖部分的新的3-O-糖基-3-脱甲基硫代秋水仙碱,并在大鼠脑和脊髓中存在的γ-氨基丁酸(gaba)和对苯丙氨酸敏感的甘氨酸受体上进行了测试.容易获得的3-O-脱甲基硫代秋水仙碱(1B)和硫代秋水仙苷(2A)使用了两种不同的合成方法.由1B和1-氟糖4获得糖基化合物2A-G.由2A制备6'-杂取代的糖基化合物6-12和6'-脱氧衍生物2H.
DOI:10.1021/jm061056S

专利信息

专利号:RU-2190598-C2
优先权日:1997-04-11
标 题 :Derivatives of thiocolchicine, methods of their synthesis, compound, pharmaceutical composition

专利号:RU-2181354-C2
优先权日:1996-06-07
标 题:Derivatives of colchicine, methods of their synthesis and pharmaceutical compositions based on thereof

专利号:US-7427690-B2
优先权日:2004-06-05
标 题 :Multifunction “crown complexes†from amino acids and peptides for skin and hair restoration
发明人：GUPTA SHYAM K
权利人:BIODERM RESEARCH
摘要:This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.