CAS: 592-95-0; 4-Isothiocyanato-1-(Methylsulfinyl)But-1-Ene

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CAS号51598-96-0 4-(METHYLTHIO)-... | CAS号28463-24-3 glucoraphenin

📜4-(甲硫基)-3-丁烯基异硫氰酸酯置于双氧水体系中,用 甲醇 作为反应溶剂,化学反应生成 莱菔素
参考文献:Cytotoxic And Antioxidant Activity Of 4-Methylthio-3-Butenyl Isothiocyanate From Raphanus Sativus L. (Kaiware Daikon) Sprouts
标题:Cytotoxic And Antioxidant Activity Of 4-Methylthio-3-Butenyl Isothiocyanate From Raphanus Sativus L. (Kaiware Daikon) Sprouts
摘要:There Is High Current Interest In The Chemopreventive Potential Of Brassica Vegetables (Cruciferae),Particularly Due To Their Content In Glucosinolates (Gl),Which Upon Myrosinase Hydrolysis,Release The Corresponding Isythiocyanates (Itc). Some Itcs,Such As Sulforaphane (Sfn) From Broccoli (Brassica Oleacea Italica),Have Been Found To Possess Anticancer Activity Through Induction Of Apoptosis In Selected Cell Lines,As Well As Indirect Antioxidant Activity Through Induction Of Phase 11 Detoxifying Enzymes. Japanese Daikon (Raphanus Sativus L.) Is Possibly The Vegetable With The Highest Per Capita Consumption Within The Brassicaceae Family. Thanks To A Recently Improved Gram Scale Production Process,It Was Possible To Prepare Sufficient Amounts Of The Gl Glucoraphasatin (Grh) As Well As The Corresponding Itc 4-Methylthio-3-Butenyl Isothiocyanate (Grh-Itc) From Its Sprouts. This Paper Reports A Study On The Cytotoxic And Apoptotic Activities Of Grh-Itc Compared With The Oxidized Counterpart 4-Methylsulfinyl-3-Butenyl Isothiocyanate (Gre-Itc) On Three Human Colon Carcinoma Cell Lines (Lovo,Hct-116,And Ht-29) Together With A Detailed Kinetic Investigation Of The Direct Antioxidant/radical Scavenging Ability Of Grh And Grh-Itc. Both Grh-Itc And Gre-Itc Reduced Cell Proliferation In A Dose-Dependent Manner And Induced Apoptosis In The Three Cancer Cell Lines. The Compounds Significantly (P < 0 05) Increased Bax And Decreased Bcl2 Protein Expression,As Well As Producing Caspase-9 And Parp-1 Cleavage After 3 Days Of Exposure In The Three Cancer Cell Lines. Grh-Itc Treatment Was Shown To Have No Toxicity With Regard To Normal Human Lymphocytes (-15 +/-5%) In Comparison With Sfn (Complete Growth Inhibition). Grh And Grh-Itc Were Able To Quench The 2,2-Diphenyl-1-Picrylhydrazyl Radical,With Second-Order Rate Constants Of 14.0 +/-2.8 And 43.1 +/-9.5 M-1 S(-1),Respectively (At 298 K In Methanol),Whereas The Corresponding Value Measured Here For The Reference Antioxidant Alpha-Tocopherol Was 425 +/-40 M-1 S(-1). Grh Reacted With H2O2 And Tert-Butyl Hydroperoxide In Water (Ph 7.4) At 37 Degrees C,With Rate Constants Of 1.9 +/-0.3 X 10(-2) And 9.5 +/-0.3 X 10(-4) M-1 S(-1) (Paralleling Recently Developed Synthetic Antioxidants) Being Quantitatively (>97%) Converted To Gre. It Is Demonstrated That Grh-Itc Has Interesting Antioxidant/radical Scavenging Properties,Associated With A Selective Cylotoxic/apoptotic Activity Toward Three Human Colon Carcinoma Cell Lines,And Very Limited Toxicity On Normal Human T-Lymphocytes.
DOI:10.1021/jf073123C

专利信息

专利号:WO-2025069039-A1
优先权日:2023-09-28
标题:An in situ process for the preparation of primary amine compounds
发明人：SAMANT RAJARAM; TONGRA MANOJ
权利人:SAMANT RAJARAM; TONGRA MANOJ
摘要:An in situ process for the preparation of primary amine compounds The invention disclosed herein relates to an in situ process for the preparation of primary amine compounds. Particularly, it relates to the preparation of primary amine compounds having general Formula (I). Formula (I) wherein n is 1 to 9 and X is -S, -N- or -O. More particularly, the present invention relates to the preparation of primary amine compounds with high yield and purity which is further used as potent intermediate in the synthesis of therapeutically active isothiocyanates (ITCs).

专利号:CN-111034616-A
优先权日:2019-12-25
标题 :A method for the synthesis and release of glucoraphanin and sulforaphane in hairy roots of broccoli

专利号:CN-102093273-B
优先权日:2010-11-29
标 题:A kind of chemical synthesis method of sulforaphane

专利号:CN-102093273-A
优先权日:2010-11-29
标 题:A kind of chemical synthesis method of sulforaphane

专利号:CN-111034616-B
优先权日:2019-12-25
标 题:A method for the synthesis and release of glucoraphanin and sulforaphane in hairy roots of broccoli

专利号:CN-105001135-B
优先权日:2015-07-10
标题:A kind of chemical synthesis method of raphacin