CAS: 5790-46-5; 1-(Isopropylamino)-3-(P-Tolyloxy)Propan-2-Ol (Bisoprolol Impurity)

相似化合物

7695-63-8 7695-63-8 67193-95-7

上下游产品

cresyl-glicidyl ether isopropylamine 1-chloro-3-(4-methylphenoxy)-2-propanol 3-Butyl-1-(2-hydroxy-3-p-tolyloxy-propyl)-1-isopropyl-urea

📜对叔丁基苯基1-(2,3-环氧)丙基醚,异丙胺置于苯酚体系中,化学反应生成 1-异丙基氨基-3-(对甲苯氧基)-2-丙醇
参考文献:由芳氧基丙醇胺的侧链取代引起的对心肌和血管β肾上腺素受体相对亲和力的改变.
标题:由芳氧基丙醇胺的侧链取代引起的对心肌和血管β肾上腺素受体相对亲和力的改变.
摘要:
DOI:10.1021/jm00205A016

专利信息

专利号:US-6239313-B1
优先权日:2000-02-16
标 题 :Process for the solid state synthesis of enantiopure B-aminoalcohols from racemic epoxides
发明人：KAKULAPATI RAMA RAO; NANDURI BHANUMATHI; ELETI RAJENDER REDDY
权利人:COUNCIL SCIENT IND RES
摘要:The invention relates to a process for the solid state synthesis of enantiopure β-aminoalcohols by preparing inclusion complexes of aryloxyepoxide with cyclodextrin by adding an epoxide in equimolar ratio in an organic solvent to an aqueous solution of cyclodextrin, reacting the cyclodextrin complex of aryloxyepoxide with a nucleophile in solid state by intimately grinding the mixture using a mortar and pestle, continuing the mixing till the starting epoxide disappeared on tic, removing excess amines under vacuum, extracting the β-aminoalcohols produced with a solvent with yields of more than 50% and enantioselectivity of upto 100%.