CAS: 56030-56-9; (+/-)-2,2',3,4,4',6-Hexachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,是合成有机化学品,以其环境持久性和潜在毒性而著称;该化合物由两个相连的苯环组成,六个氯原子在特定位置上被替换,有助于其稳定性和降解抗药性;它一般是无色的,不光黄色固体,水中挥发性低,溶解性低,但在有机溶剂和油中可溶解;由于其疏水性,它往往在活生物体的脂肪组织中蓄积,导致生物累积和食物链中潜在的生物放大作用;六氯联苯与各种不良健康影响有关,包括内分泌干扰和致癌性,促使采取管制行动限制其使用和释放到环境中;它在生态系统中的持久性引起了对长期生态和人类健康的影响的关切,使其成为持续进行环境监测和补救的主体.

英文名称(+/-)-2,2',3,4,4',6-Hexachlorobiphenyl
中文名称2,2',3,4,4',6-六氯联苯
IUPAC名称1,2,3,5-tetrachloro-4-(2,4-dichlorophenyl)benzene
其它别名1,1'-Biphenyl,2,2',3,4,4',6-hexachloro-, (?à)-; (?à)-2,2',3,4,4',6-Hexachloro-1,1'-biphenyl; 2,2',3,4,4',6-Hexachloro-1,1'-biphenyl; 2,2',3,4,4',6-Hexachlorobiphenyl; 2,3,4,6,2',4'-Hexachlorobiphenyl
CAS编号56030-56-9
FDA UNII编号:LH9A94Y4LL
分子式:C12H4Cl6分子量:359.841461
产品CID: 1532558
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: SPOPSCCFZQFGDL-UHFFFAOYSA-N
1S/C12H4Cl6/c13-5-1-2-6(7(14)3-5)10-8(15)4-9(16)11(17)12(10)18/h1-4H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,3,4,6-tetrachloroiodobenzene 2,4-dichloro-1-iodo-benzene 1,2,3,7-tetrachlorodibenzofuran 1,2,3,6,7-pentachlorodibenzofuran 1,3,4,7-tetrachlorodibenzofuran

合成工艺路线路线简述

📜1,2,3,5-四氯-4-碘苯,2,4-二氯-1-碘苯置于铜体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应生成 2,2',3,4,4',6-六氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4