CAS: 5391-88-8; 1-(4-Bromophenyl)Ethanol

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4-(α-acetoxyethyl)-1-bromobenzene (-)-(S)-N,N-dimethyl-1-phenylethylamine acetic anhydride para-bromoacetophenone (R)-1-(4-trimethylsilylethynylphenyl)ethanol (R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide (R)-2-(4-bromophenyl)-2-cyclopropylpropanal (R)-2-(4-bromophenyl)-2-cyclopropylpropanal oxime

📜4-溴苯乙酮置于c17H28Clirn2Os,氢气,Sodium Methylate体系中,用 甲醇 作为反应溶剂,40.0 °C,2.5 Mpa 条件下,反应 1.0H,以99%的收率获得产物1-(4-溴苯基)-1-乙醇
参考文献:为什么 M/nh 双功能 Noyori 型催化剂中 N-H 官能团的烷基化会导致营业额
标题:为什么 M/nh 双功能 Noyori 型催化剂中 N-H 官能团的烷基化会导致营业额
摘要:分子金属/nh 双功能 Noyori 型催化剂的显着之处在于它们是迄今为止开发的用于羰基官能团氢化的最有效的人工催化剂之一(负载量高达 10-5 Mol%).此外,这些催化剂通常表现出高 C=o/c=c 化学和对映选择性.这组独特的性质传统上与均相催化剂的非常规机制的操作有关,其中螯合配体通过其 Nh 键传递/接受质子 (H+) 在促进催化反应和实现上述选择性方面发挥关键作用解理/形成.最近修订的 Noyori 氢化反应机理 (Dub,Pa Et Al. J. Am. Chem. Soc. 2014,136,3505) 表明 Nh 键没有裂解,而是通过强 Nh...o 氢键相互作用 (Hbi) 来稳定转换决定过渡态 (Tdts).本论文表明,这与很大程度上被忽略的实验事实一致,即 M/nh 双功能 Noyori 型催化剂中 Nh 官能团的烷基化导致不利的催化活性.这项工作的目的是证明降低这种
DOI:10.1021/jacs.6B11666

专利信息

专利号:US-5075450-A
优先权日:1990-06-28
标 题 :Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes
发明人：RASMUSSON GARY H; TOLMAN RICHARD L; PATEL GOOL F
权利人:MERCK & CO INC
摘要:New intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes, of the formula: ##STR1## wherein R 2 is 2-thiopyridyl, and n R 3 is C 2 -C 4 alkoxycarbonyl, C 1 -C 4 , or trifluoromethylsulfonyloxy. The above compounds are useful intermediates in producing testosterone 5α-reductase inhibitors which are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.

专利号:US-11584773-B2
优先权日:2014-04-30
标 题:Phosphorous protecting groups and methods of preparation and use thereof
发明人：DELLINGER DOUGLAS J; MONFREGOLA LUCA; CARUTHERS MARVIN; ROY MITHUN
权利人:AGILENT TECHNOLOGIES INC
摘要:Aspects of the present disclosure include compositions that make use of phosphorus and/or nucleobase protecting groups which find use in the synthesis of long polynucleotides. Phosphorus protecting groups are provided that help increase the stepwise coupling yield and/or phosphorous protecting groups that can be removed during the oxidation step. Amidine nucleobase protecting groups are provided that find use in the subject compositions and methods which provides for e.g., increased resistance to depurination during polynucleotide synthesis. In some instances, the methods and compositions disclosed herein utilize a combination of the phosphorus and amidine nucleobase protecting groups in the synthesis of polynucleotides having a sequence of 200 or more monomeric units in length. Also provided are methods for synthesizing a polynucleotide (e.g., a DNA) using one or more compounds disclosed herein.

专利号:CN-108101741-A
优先权日:2017-12-05
标题 :A method for the tandem synthesis of chiral alcohols by hydration/asymmetric hydrogenation of alkynes

专利号:CN-107522741-A
优先权日:2017-09-04
标题 :A new method for the synthesis of phosphate compounds

专利号:CN-107098829-A
优先权日:2017-06-21
标 题:A method for continuous flow synthesis of α-ketoamides using micro-flow field technology

专利号:CN-107098829-B
优先权日:2017-06-21
标 题 :A method for continuous flow synthesis of α-ketoamides using microfluidic field technology