CAS: 469-59-0; (2'R,3S,3'R,3A'S,6As,6Bs,6'S,7A'R,11As,11Br)-3-Hydroxy-3',6',10,11B-Tetramethyl-1,3,3A',4,4',5',6,6A,6B,6',7,7',7A',8,11A,11B-Hexadecahydro-3'H-Spiro[benzo[a]Fluorene-9,2'-Furo[3,2-B]Pyridin]-11(2H)-One

该化合物是一种自然产生的藻类,主要存在于某些植物物种中,特别是称为Liliaceae的植物家族中.它被归类为一种血压藻类,在结构上与其他化合物,如乙酸甲胺和环...

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CAS号17008-94-5 (23R)-17,23-epo... | CAS号17008-98-9 (23R)-28-acetyl... | CAS号17009-00-6 (23R)-28-acetyl... | CAS号17008-93-4 (23R)-28-acetyl... | CAS号17009-03-9 N-acetyljervine | CAS号14788-78-4 O-Acetyljervine | CAS号4449-51-8 环巴胺 | CAS号18113-81-0 2-乙基-5-甲基吡啶

合成工艺路线路线简述

    📜(23R)-28-Acetyl-17,23-Epoxy-3β-Hydroxy-(5α)-Veratr-12-En-11-One置于钯 Chromium(Vi) Oxide,氢氧化钾,Sodium Tetrahydroborate,氢气,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 二甲基亚砜,N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 蒜黎芦碱
    参考文献:C-Nor-D-Homosteroids And Related Alkaloids. Ix. Synthesis Of Jervine And Related Alkaloids
    标题:C-Nor-D-Homosteroids And Related Alkaloids. Ix. Synthesis Of Jervine And Related Alkaloids
    摘要:
    DOI:10.1021/ja00993A048

    海关参考信息

    专利信息


    专利号:EP-3137618-A1
    优先权日:2014-04-29
    标 题 :Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds

    专利号:US-2017058305-A1
    优先权日:2014-04-29
    标 题:Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

    专利号:US-2021198706-A1
    优先权日:2014-04-29
    标题 :Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

    专利号:WO-2015164960-A1
    优先权日:2014-04-29
    标 题:Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds

    专利号:CN-111393318-B
    优先权日:2020-04-13
    标题 :Synthesis of aleuritopteris forbesii acid amide derivative and application of aleuritopteris forbesii acid amide derivative in antitumor drugs

    专利号:US-2012083419-A1
    优先权日:1997-06-20
    标 题 :Method and compositions for inhibiting tumorigenesis
    发明人:ALTABA ARIEL RUIZ I; DATTA SUMANA; DATTA MILTON
    权利人:ALTABA ARIEL RUIZ I; DATTA SUMANA; DATTA MILTON
    摘要:The present invention relates to compounds, small interfering RNAs and compositions and methods of inhibiting tumorigenesis and methods of inhibiting tumor cell growth and proliferation using agents that inhibit the hedgehog and Gli signaling pathway, including agents that inhibit GLI synthesis and/or function. The present invention also relates to particular biomarkers that can be used in the diagnosis and prognosis of prostate cancer. Methods of treating cancer, including prostate cancer are also provided using small organic compounds, siRNAs and blocking antibodies that inhibit or block the SHH/GLI pathway.

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    合成参考文献


    参考文献:10.1002/cyto.a.21103
    摘要:Balbuena J, Pachon G, Lopez-Torrents G, Aran JM, Castresana JS, Petriz J. ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties. Cytometry A. 2011 Sep;79(9):672–83. doi: 10.1002/cyto.a.21103.
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