CAS: 42779-56-6; 2,4-Dichloro-6-Methylpyridine

相似化合物

18368-63-3 40314-71-4 132683-62-6

上下游产品

4-hydroxy-6-methyl-2-pyridone 2,4-dihydroxy-6-methylpyridine trichlorophosphate phosphorus pentachloride α-picoline 4,6-dichloro-2-pyridinecarboxylic acid 2,4-dihydroxy-6-methylpyridine (E)-1-(2-chlorobenzylidene)-2-(4-chloro-6-methylpyridin-2-yl)hydrazine

6-Methyl-1,2-Dihydropyridine-2,4-Diol置于三氯氧磷体系中,化学反应 36.0H,以5.18 G的收率获得产物2,4-二氯-6-甲基吡啶
参考文献:Dihydropyrrole[2,3-D]Pyridine Derivatives As Novel Corticotropin-Releasing Factor-1 Antagonists: Mapping Of The Receptor Binding Pocket By In Silico Docking Studies
标题:Dihydropyrrole[2,3-D]Pyridine Derivatives As Novel Corticotropin-Releasing Factor-1 Antagonists: Mapping Of The Receptor Binding Pocket By In Silico Docking Studies
摘要:In An Effort To Discover Novel Crf-1 Receptor Antagonists Exhibiting Improved Physicochemical Properties,A Dihydropirrole[2,3]Pyridine Scaffold Was Designed And Explored In Terms Of The Sar Of The Substitution At The Pendent Phenyl Ring And The Nature Of The Heterocyclic Moieties Present In The Upper Region Of The Molecule. Selective And Potent Compounds Have Been Discovered Endowed With Reduced Clogp With Respect To Compounds Known In The Literature. Of Particular Relevance Was The Finding That The In Vitro Affinity Of The Series Was Maintained By Reducing The Overall Lipophilicity. The Results Achieved By This Exploration Enabled The Formulation Of A Novel Hypothesis On The Nature Of The Receptor Binding Pocket Of This Class Of Crf-1 Receptor Antagonists,Making Use Of In Silico Docking Studies Of The Putative Nonpeptidic Antagonist Binding Site Set Up In House By Homology Modeling Techniques.
DOI:10.1021/jm800743Q

专利信息

专利号:US-2023399302-A1
优先权日:2020-10-29
标题:Process for the preparation of heteroaryl-substituted sulfur(vi) compounds
发明人：LOPCHUK JUSTIN M; SHULTZ ZACHARY P; SCATTOLIN THOMAS
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.