CAS: 37444-46-5; Pyridazin-3-Ylmethanol

上下游产品

CAS号41991-02-0 acetic acid,(2,... | CAS号623-17-6 乙酸糠酯 | CAS号60170-83-4 哒嗪-3-甲醛 | CAS号2164-61-6 3-羧基哒嗪 | CAS号27349-66-2 3-(氯甲基)哒嗪盐酸盐

专利信息

专利号:US-2011319644-A1
优先权日:2006-11-02
标 题:Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
发明人：TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO
权利人:TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO
摘要:A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted with a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovitamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from the 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10-olefincyclovitamin D derivative. The 1-hydrocyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norviatmin D derivative. Thus provided are a novel process for production of 1-hydroxy-19-norcyclovitamin D derivative that is utilizable as an intermediate in the synthesis of 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production.