CAS: 2743-40-0; H-Leu-Oet.Hcl

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17016-87-4 2743-60-4 73913-65-2

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CAS号64-17-5 乙醇 | CAS号61-90-5 L-亮氨酸 | CAS号37787-76-1 (L)-N-B°C leuci... | CAS号7533-40-6 L-亮氨醇 | CAS号3253-28-9 Leucine,N-[N-(b... | CAS号1421-69-8 Z-Gly-Leu-OH | CAS号73401-65-7 B°C-亮氨酰-亮氨酸 | CAS号78603-97-1 (S)－(－)－2－氨－4－甲... | CAS号62246-49-5 ethyl 2-isothio... | CAS号64505-10-8 2-异氰酰-4-甲基戊酸乙酯

L-亮氨酸置于氯化亚砜体系中,用 乙醇 用作溶剂,化学反应生成L-亮氨酸乙酯盐酸盐
参考文献:N-Heterocyclic Alcohol Renin Inhibitors
标题:N-Heterocyclic Alcohol Renin Inhibitors
摘要:公式为##str1##的化合物被披露,其中r.Sub.1是n-杂环基团.这些化合物通过抑制肾素干预将血管紧张素转化为血管紧张素ii,因此可用作降压药物.

专利信息

专利号:WO-9305065-A1
优先权日:1991-08-30
标 题:Preparation of peptides by a solid-phase synthesis and intermediates therefor
发明人：SHARMA RAM PRAKASH
权利人:PORTON DEV LTD
摘要:The invention relates to the preparation of polypeptides by solid phase synthesis by attachment of carboxy-protected amino acids to the carboxyl end of a peptide chain bound at its N-terminal to a solid support. The carboxy-protection is by a tertiary alkoxy silyl group. Novel tertiary alkoxy silyl amino acid esters are disclosed which may be used as intermediates.

专利号:US-2012282652-A1
优先权日:2011-02-28
标题 :Preparation of peptide mixtures by protease catalysis designed to provide useful biological and physical properties
发明人：GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU
权利人:GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU; POLITECHNIC INST UNIV NEW YORK
摘要:A process for preparing unique peptide mixtures with a broad range of uses using combinations of natural and non-natural amino acid alkyl ester monomers and specific combinations of these monomers as dimers, trimers and higher oligomers selected from the large group of structural motifs that lead to useful physical and/or biological properties and that have been or may be identified from solid state peptide synthesis, isolation of peptides from natural sources, and production of peptides by recombinant DNA methods, or identification of peptides by recombinant methods such as phage display, the method of peptide synthesis comprising a) admixing one or more natural and non-natural amino acid alkyl ester monomer, dimer, trimer and higher oligomers with one or more proteases in a reaction medium; b) heating the mixture to between about 5° C. to about 90° C. for between 5 minutes and 24 hours; and c) recovering the formed oligopeptide.

专利号:US-2006252134-A1
优先权日:1999-10-29
标 题 :Enantioselective oligomerization of alpha-hydroxy carboxylic acids and alpha-amino acids
发明人：LORBERT STEVE; SCHASTEEN CHARLES S; URAIZEE FAROOQ; KAPILA SHUBHENDER
权利人:NOVUS INT INC
摘要:An enzymatic synthesis and composition of oligomers and co-oligomers comprised of α-hydroxy carboxylic acids and α-amino acids or peptides is disclosed. In a preferred embodiment, a α-hydroxy carboxylic acid with a specific chiral configuration is linked by an amide linkage to a α-amino acid specific with a specific chiral configuration or linked by an amide linkage to a peptide made up of α-amino acid monomers having identical chiral configurations. Proteolytic enzymes catalyze oligomerization of the α-hydroxy carboxylic acid and α-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to animals such as ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen and other animals such as swine, poultry and aquatic animals.

专利号:US-6939693-B2
优先权日:1999-10-29
标 题 :Enantioselective oligomerization of α-hydroxy carboxylic acids and α-amino acids
发明人：LORBERT STEPHEN J; SCHASTEEN CHARLES S; NAM PAUL K S; FORCINITI DANIEL; RAJESH MATHUR P; KAPILA SHUBHENDER
权利人:NOVUS INT INC
摘要:An enzymatic synthesis and composition of oligomers and co-oligomers comprised of α-hydroxy carboxylic acids and α-amino acids or peptides is disclosed. In a preferred embodiment, a α-hydroxy carboxylic acid with a specific chiral configuration is linked by an amide linkage to a α-amino acid specific with a specific chiral configuration or linked by an amide linkage to a peptide made up of α-amino acid monomers having identical chiral configurations. Proteolytic enzymes catalyze oligomerization of the α-hydroxy carboxylic acid and α-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to animals such as ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen and other animals such as swine, poultry and aquatic animals.

专利号:US-6605590-B1
优先权日:1999-10-29
标题 :Oligomers and oligomeric segments of alpha-hydroxy carboxylic acids and alpha-amino acids
发明人：LORBERT STEPHEN J; SCHASTEEN CHARLES S; NAM PAUL K S; FORCINITI DANIEL; RAJESH MATHUR P; KAPILA SHUBHENDER
权利人:NOVUS INT INC
摘要:An enzymatic synthesis and composition of alpha-hydroxy carboxylic acid and alpha-amino acid or peptide co-oligomers is disclosed wherein a residue of the alpha-hydroxy carboxylic acid is linked to a residue of the alpha-amino acid or peptide by an amide linkage. Proteolytic enzyme papain catalyzes co-oligomerization of the alpha-hydroxy carboxylic acid and alpha-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen.

专利号:US-8461289-B2
优先权日:2006-10-17
标 题:Bioresorbable polymers synthesized from monomer analogs of natural metabolites
发明人：KOHN JOACHIM B; BOLIKAL DURGADAS
权利人:KOHN JOACHIM B; BOLIKAL DURGADAS; UNIV RUTGERS
摘要:New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles.