CAS: 17791-37-6; (2R,3R,4S,5R,6S)-3,4,5-Tris(Benzyloxy)-2-((Benzyloxy)Methyl)-6-Methoxytetrahydro-2H-Pyran

上下游产品

methanol phenyl 2,3,4,5-tetra-O-benzyl-1-thio-β-D-glucopyranoside 2,3,4,6-tetra-O-benzyl-D-glucopyranose 2,3,4,6-Tetra-O-benzyl-D-glucopyranose2-methyl-3-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)propene 2-methyl-3-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)propene 3-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)butene 2-bromo-3-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)propene

📜1-硫代-B-甲基葡萄糖甙-4-甲基苯酯置于sodium Hydride体系中,用 N,N-二甲基甲酰胺,乙腈 用作溶剂,化学反应 4.0H,反应生成甲基 2,3,4,6-O-四苄基-Alpha-D-吡喃葡萄糖苷
参考文献:Balovoine,Gilbert; Berteina,Sabine; Gref,Aurore,Journal Of Carbohydrate Chemistry,1995,Vol. 14,# 8,P. 1217-1236
标题:Balovoine,Gilbert; Berteina,Sabine; Gref,Aurore,Journal Of Carbohydrate Chemistry,1995,Vol. 14,# 8,P. 1217-1236

专利信息

专利号:US-9775856-B2
优先权日:2012-03-09
标题 :C-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of Genista tenera ethyl acetate extracts containing some of those agents
发明人：GRASES SANTOS SILVA RAUTER AMÉLIA PILAR; XAVIER DE JESUS ANA RITA; MENDES MARTINS ALICE ISABEL; DOS SANTOS DIAS CATARINA ALEXANDRA; TAVARES RIBEIRO ROGÉRIO JOSÉ; BORGES DE LEMOS MACEDO MARIA PAULA; GUERRA JUSTINO JORGE ALBERTO; DIAS MOTA FILIPE HELDER; AMARO PINTO RUI MANUEL; NOGUEIRA SEPODES BRUNO MIGUEL; PATRÃ?CIO GOULART DE MEDEIROS MARGARIDA ALEXANDRA; JIMENÉZ BARBERO JESUS; AIROLDI CRISTINA; NICOTRA FRANCESCO
权利人:FACULDADE DE CIENCIAS DA UNIV DE LISBOA
摘要:The present invention concerns the antidiabetic-activity of compounds type A, namely of 8-β-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to β-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic, agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. n The inhibitory activity of α-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphatase by these two extracts and the diethyl ether plant extract is also part of the present invention.

专利号:US-5627270-A
优先权日:1991-12-13
标题:Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
发明人：KAHNE DANIEL E; KAHNE SUZANNE W; SOFIA MICHAEL J; HATZENBUHLER NICOLE T
权利人:UNIV PRINCETON; TRANSCELL TECHNOLOGIES INC
摘要:Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is provided. Methods for the permeabilization of membranes and the enhancement of the activity of predetermined compounds are also provided.

专利号:US-2017348340-A1
优先权日:2012-03-09
标题 :New c-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of genista tenera ethyl acetate extracts containing some of those agents
发明人：GRASES SANTOS SILVA RAUTER AMÉLIA PILAR; XAVIER DE JESUS ANA RITA; MENDES MARTINS ALICE ISABEL; DOS SANTOS DIAS CATARINA ALEXANDRA; TAVARES RIBEIRO ROGÉRIO JOSÉ; BORGES DE LEMOS MACEDO MARIA PAULA; GUERRA JUSTINO JORGE ALBERTO; DIAS MOTA FILIPE HELDER; AMARO PINTO RUI MANUEL; NOGUEIRA SEPODES BRUNO MIGUEL; PATRÃ?CIO GOULART DE MEDEIROS MARGARIDA ALEXANDRA; JIMENÉZ BARBERO JESUS; AIROLDI CRISTINA; NICOTRA FRANCESCO
权利人:UNIV DE LISBOA; INST POLITÉCNICO DE SANTARÉM
摘要:The present invention concerns the antidiabetic activity of compounds type A, namely of 8-β-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to β-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. n The inhibitory activity of β-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphastase by these two extracts and the diethyl ether plant extract is also part of the present invention.

专利号:US-5693769-A
优先权日:1991-12-13
标 题 :Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
发明人：KAHNE DANIEL EVAN; KAHNE SUZANNE WALKER
权利人:TRANSCELL TECHNOLOGIES INC; UNIV PRINCETON
摘要:Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is provided. Methods for the permeabilization of membranes and the enhancement of the activity of predetermined compounds are also provided.

专利号:US-4207413-A
优先权日:1977-04-22
标 题 :L-Sucrose and process for producing same
发明人：JONES JOHN K N; SZAREK WALTER A
权利人:QUEEN S UNIV
摘要:L-sucrose or beta -L-fructofuranosyl alpha -L-glucopyranoside-(I), the enantiomer of naturally occuring D-sucrose, which does not appear in nature has been synthesized and has been found to be sweet. It is unlikely that L-sucrose is metabolized in the manner of D-sucrose. In a preferred process for producing L-sucrose the key step is the condensation of 2,3,4,6-tetra-O-benzyl- alpha -L-glucopyranosyl chloride-(II) with 1,3,4,6-tetra-O-benzyl-L-fructofuranose-(III). Compound II is obtained from L-glucose by way of 2,3,4,6-tetra-O-benzyl- alpha -L-glucopyranose; and L-glucose is prepared from L-arabinose by nitromethane synthesis. Compound III is obtained by oxidation, with Jones reagent, of 1,3,4,6-tetra-O-benzyl-L-mannitol which, in turn, is prepared from L-mannose. The condensation product of II and III is catalytically debenzylated to produce L-sucrose.