CAS: 1735-54-2; 4-Chloro-3-(Trifluoromethyl)Benzonitrile

该化合物是一种多用途芳烃硝酸铵化合物,其特点是苯环上的氯和三氟甲基替代物,其电子退出组增强了反应性,使其成为有机合成中的宝贵中间体,特别是在制药和农用化学应用中.三氟甲基组有助于提高脂性稳定度和代谢稳定性,而氯子组则具有进一步的功能化潜力.该化合物通常用于交叉反应,核分裂哲学替代以及作为三氟甲基环球框架的前体.其高纯度和明确界定的结构确保研究和工业流程的一致性能.在受控制的条件下使用,因其具有再活动性,需要适当的处理.

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物理性质

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CAS号320-51-4 5-氨基-2-氯三氟甲苯 | CAS号1737-36-6 3-三氟甲基-4-氯苯甲酸

合成工艺路线路线简述

    📜2-氯-5-氨基三氟甲苯置于potassium Tetracyanocuprate (I)体系中,化学反应生成3-三氟甲基-4-氯苯腈
    参考文献:Compounds Of The Triphenylmethane Series
    标题:Compounds Of The Triphenylmethane Series

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    专利信息


    专利号:US-4822903-A
    优先权日:1981-05-15
    标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
    发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
    权利人:RHONE POULENC SPEC CHIM
    摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

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    合成参考文献


    摘要:Subramanian, L. R., Science of Synthesis, (2004) 19, 221.
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