CAS: 16320-04-0; Gestrinone

专利信息

专利号:US-12054512-B2
优先权日:2017-11-10
标 题 :Sting modulator compounds, and methods of making and using
发明人：VYSKOCIL STEPAN; CIAVARRI JEFFREY; CULLIS COURTNEY; ENGLAND DYLAN BRADLEY; GOULD ALEXANDRA E; GREENSPAN PAUL; HU YONGBO; LANGSTON STEVEN; LI GANG; MIZUTANI HIROTAKE; OKANIWA MASANORI
权利人:TAKEDA PHARMACEUTICALS CO
摘要:The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.The present disclosure relates to a compound represented by the Formula (I):wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

专利号:US-7504543-B2
优先权日:2004-03-18
标 题:Polyether alcohols and method for the production of polyether alcohols for polyurethane synthesis
发明人：RUPPEL RAIMUND; BAUM EVA; OSTROWSKI THOMAS; HARRE KATHRIN; BLEUEL ELKE
权利人:BASF AG
摘要:The invention relates to polyether alcohols, to a process for preparing polyether alcohols by reacting alkylene oxides in the presence of a double metal cyanide (DMC) catalyst with at least one saturated OH component which may, if appropriate, have previously been reacted with an alkylene oxide, wherein an antioxidant is added before or during the reaction, and also to the further processing of the polyether alcohols to form polyurethanes.

专利号:US-8093415-B2
优先权日:2001-11-16
标题:Polyunsaturated fatty acid monovalent and divalent metal salt synthesis
发明人：LUCHINI DANIEL NESTOR; STROHMAIER GEORGE K; FREDERIKSEN EILER D; HAWKES JAMES G; DULL BOB J
权利人:LUCHINI DANIEL NESTOR; STROHMAIER GEORGE K; FREDERIKSEN EILER D; HAWKES JAMES G; DULL BOB J; VIRTUS NUTRITION LLC
摘要:Methods for the preparation of a free-flowing, storage-stable fatty acid metal salt product by forming a reactive admixture of (a) an unsaturated fatty acid glyceride feedstock; and (b) from about 1 mol to about 3 mol of at least one monovalent metal hydroxide or at least one divalent metal hydroxide; and heating the admixture to a temperature at which said fatty acid glycerides saponify to form fatty acid metals salts; wherein said monovalent metal is potassium; and wherein said divalent metal is selected from the group consisting of calcium, copper, magnesium and zinc. The fatty acid glycerides are saponified in an atmosphere in which the partial pressure of oxygen has been reduced by an amount effective to provide an improvement in storage stability until a free-flowing, storage-stage product is obtained. Storage stable metal salts of unsaturated fatty acids prepared by the inventive methods are also disclosed.

专利号:EP-1765964-A4
优先权日:2004-04-30
标 题:SYNTHESIS OF METALLIC SALTS OF MONOVALENT AND DIVALENT POLYUNSATURATED FATTY ACIDS

专利号:US-2008280877-A1
优先权日:2007-05-10
标 题:Azetidines
发明人：DACK KEVIN NEIL; SKERRATT SARAH ELIZABETH; YEAP SIEW KUEN
权利人:PFIZER
摘要:The invention relates to EP2 antagonist azetidines of formula (I) n n n n n n n n n n wherein Ar, R 1 , X, and Z are as defined herein, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids, to intermediates useful in their synthesis, and to compositions containing them.

专利号:US-2010256109-A1
优先权日:2007-11-15
标 题 :Azetidines As EP2 Antagonists
发明人：SKERRATT SARAH ELIZABETH; DACK KEVIN NEIL
权利人:SKERRATT SARAH ELIZABETH; DACK KEVIN NEIL
摘要:The present invention relates to a class of EP2 antagonistazetidines of general formula (I), wherein the variables and substituents are as defined herein, and especially to EP2 antagonist compounds, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids (leiomyomata) and to intermediates usefulin their synthesis and to compositions containing them.