专利号:US-9382288-B2 优先权日:2010-10-06 标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action 发明人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO 权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG 摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).
专利号:WO-0026406-A1 优先权日:1998-11-04 标题:METHOD FOR INDEXING AND DETERMINING THE RELATIVE CONCENTRATION OF EXPRESSED MESSENGER RNAs 发明人:HASEL KARL W; HILBUSH BRIAN S 权利人:DIGITAL GENE TECH INC 摘要:An improved method for the simultaneous sequence-specific identification of mRNAs in a mRNA population allows the visualization of nearly every mRNA expressed by a tissue as a distinct band on a gel whose intensity corresponds roughly to the concentration of the mRNA. In general, the method comprises the formation of cDNA using anchor primers to fix a 3'-endpoint, producing cloned inserts from the cDNA in a vector containing a bacteriophage-specific promoter for subsequent RNA synthesis, generating linearized fragments of the cloned inserts, preparing cRNA, transcribing cDNA from the cRNA and performing two sequence specific PCR amplifications of the cDNA. In preferred embodiments, the method comprises comparing the length and at least part of the nucleotide sequence of the PCR products to expected values determined from a database of nucleotide sequences. The method can identify changes in expression of mRNA associated with the administration of drugs or with physiological or pathological conditions. Also provided are vectors and primers useful for the practice of the improved method.
专利号:US-2014315720-A1 优先权日:2012-10-24 标 题 :Polysaccharide ester microspheres and methods and articles relating thereto 发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY 权利人:CELANESE ACETATE LLC 摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
专利号:CN-109651246-A 优先权日:2018-12-28 标题 :A kind of new synthesis method of sodium pyrithione
专利号:CN-108373446-B 优先权日:2018-03-26 标 题 :Synthesis method of high-quality zinc pyrithione
1: Jing M, Chen Z, Li Z, Li F, Chen M, Zhou M, He B, Chen L, Hou Z, Chen X. Facile Synthesis of ZnS/N,S Co-doped Carbon Composite from Zinc Metal Complex for High-Performance Sodium-Ion Batteries. ACS Appl Mater Interfaces. 2018 Jan 10;10(1):704-712. doi: 10.1021/acsami.7b15659. Epub 2017 Dec 28. doi: 10.1016/j.mimet.2017.08.005. Epub 2017 Aug 10. doi: 10.1007/s12011-015-0423-3. Epub 2015 Jul 4. doi: 10.1021/ac3036102. Epub 2013 Feb 12. doi: 10.1016/j.chemosphere.2012.02.070. Epub 2012 Apr 4. doi: 10.1080/08927014.2011.594162. doi: 10.1016/j.bbrc.2010.07.004. Epub 2010 Jul 16. doi: 10.1186/1465-9921-11-65. 9: Arias-Barreiro CR, Okazaki K, Koutsaftis A, Inayat-Hussain SH, Tani A, Katsuhara M, Kimbara K, Mori IC. A bacterial biosensor for oxidative stress using the constitutively expressed redox-sensitive protein roGFP2. Sensors (Basel). 2010;10(7):6290-306. doi: 10.3390/s100706290. Epub 2010 Jun 24. 10: Lind SE, Park JS, Drexler JW. Pyrithione and 8-hydroxyquinolines transport lead across erythrocyte membranes. Transl Res. 2009 Sep;154(3):153-9. doi: 10.1016/j.trsl.2009.06.002. Epub 2009 Jul 4. doi: 10.1080/10934520802329794. Epub 2007 Nov 29.
合成参考文献
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