CAS: 15662-33-6; Ryanodine

该化合物是自然产生的碱性碱性物质,产自植物* Ryania speciosa* ,主要以其作为肌肉细胞中钙释放的强大调控器的作用而著称,它专门针对对来自沙子晶体再结的钙离子释放至关重要,从而影响肌肉收缩和放松过程的彩虹受体(RyRs),该化合物展示了一个复杂的结构,其特点是双环核心和若干功能组,有助于其生物活动.瑞安丁经常用于药物研究,研究肌肉生理学,并影响了解各种肌肉紊乱.此外,它还因其对心血管和光滑肌肉组织的潜在影响而受到调查.由于它在钙导管方面采取了具体行动,因此,在与钙调控有关的条件下开发治疗剂也引起了兴趣.然而,由于它的毒性及其在实验环境中谨慎使用的必要性而受到限制.总的来说,ryanodine是基础生物和应用生物研究的宝贵工具.

结构式图片

欧盟法规

统一分类与标签ECHA物质工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号94513-55-0 9,21-二氢-鱼尼丁-3-(... | CAS号106821-53-8 N,4-O,10-O,15-O... | CAS号97457-25-5 N,O(sup 15)-Dim... | CAS号106821-49-2 4,7,8a,8b-tetra... | CAS号106821-50-5 N,4-O,15-O-trim... | CAS号106821-47-0 N-Benzylryanodine | CAS号33068-29-0 24,25,26-tribro...

合成工艺路线路线简述

    📜9,21-二氢-鱼尼丁-3-(1H-吡咯-2-羧酸)置于palladium On Activated Charcoal 氢气体系中,用 水 用作溶剂,化学反应 1.0H,以3%的收率获得鱼尼汀
    参考文献:Waterhouse,Andrew L.; Holden,Ian; Casida,John E.,Journal Of The Chemical Society. Perkin Transactions Ii,1985,P. 1011-1016
    标题:Waterhouse,Andrew L.; Holden,Ian; Casida,John E.,Journal Of The Chemical Society. Perkin Transactions Ii,1985,P. 1011-1016

    海关参考信息

    专利信息


    专利号:US-2023339844-A1
    优先权日:2020-09-17
    标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
    发明人:MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU
    权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
    摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

    专利号:WO-2021033172-A1
    优先权日:2019-08-20
    标题:Process for the preparation of chlorantraniliprole
    发明人:V ASHWIN; PRADHAN ASHOK KUMAR; PALIMKAR SANJAY SAMBHAJIRAO; MANE AVINASH SHESHRAO; KUNHIMON SYAM KUMAR UNNIARAN
    权利人:EUROFINS ADVINUS LTD
    摘要:The present invention relates to two novel, efficient and one-pot methods for synthesizing chlorantraniliprole. In the first scheme, Chlorantraniliprole is prepared by a novel telescopic process starting from 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid a key raw material-A (Key RM-A). In the second scheme, starting from Key RM-A, the process steps use of a novel variant of anthranilic acid (Methyl 2-amino-5-chloro-3-methylbenzoate), to get Chlorantraniliprole. Furthermore, the present invention also relates to the synthesis of key starting material for the synthesizing chlorantraniliprole in-situ. All the in-situ steps of the disclosed synthesis methods obtain good yield, without using any expensive reagent or base or harsh reaction conditions, which makes the process simple, environment friendly and more cost effective. With this process the production cost of chlorantraniliprole and its intermediates is substantially reduced; fewer by-products are formed during its synthesis and since it's a one-pot reaction, isolation and purification are easy to achieve.

    专利号:US-11718584-B2
    优先权日:2019-02-22
    标题 :Process for the synthesis anthranilic diamide compounds and intermediates thereof
    发明人:KARRI PHANEENDRASAI; PABBA JAGADISH; SHINDE BHARAT UTTAMRAO; KALWAGHE AMOL DNYANESHWAR; MADHAVRAO KAMBLE MARUTI; KLAUSENER ALEXANDER G M; PANMAND DEEPAK SHANKAR
    权利人:PI INDUSTRIES LTD
    摘要:The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), n n n n n n n n n n wherein, R 1 , R 2 , R 3a , R 3b , R 3c , R 4 , R 5 , R 6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va)

    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-9574189-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries
    发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
    权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
    摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

    专利号:US-9180171-B2
    优先权日:2011-01-25
    标题 :Method of regulating fertilizing ability using cyclic ADP-ribose and CD38
    发明人:KIM UH-HYUN; PARK KWANG-HYUN; KIM BYUNG-JU
    权利人:NAT UNIV CHONBUK IND COOP FOUND
    摘要:The present invention relates to a pharmaceutical composition for promoting fertilization comprising cyclic ADP-ribose or its derivative, CD38 and to a method of promoting fertilization by promoting the synthesis of cyclic ADP-ribose to increase sperm motility. Also, the present invention relates to a pharmaceutical composition for contraception and a method for inhibiting fertilization, which can inhibit the expression or function of cyclic ADP-ribose to reduce sperm motility, thereby inhibiting fertilization.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Guide to the Chemicals Used in Crop Protection., 6(450), 1973
    摘要:World Review of Pest Control., 9(119), 1970
    摘要:Special Publication of the Entomological Society of America., 78-1(5), 1978
    摘要:Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969, -(522), 1969
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