CAS: 1498-96-0; 4-Butoxybenzoic Acid

该化合物是一种苯并酸衍生物,其特征是,在准位置上存在一种但氧替代物.这种化合物通常用作有机合成的中间体,特别是在液晶材料,药品和特殊化学品的生产中.其结构在有机溶剂中具有有利的溶解性,增强了其在蒸发和混合反应中的回活性.但氧酸组有助于提高热稳定性,使之适合在高温下需要受控再活动的应用.此外,其晶体形式确保了处理和储存的便利性.该化合物的多功能性和定义明确的化学特性使它成为研究和工业流程中有价值的试剂.

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5736-88-9 6214-45-5 5438-19-7

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合成工艺路线路线简述

    📜4-丁氧基苯甲醛置于氢氧化钾,Silver Nitrate体系中,用 乙醇 用作溶剂,化学反应 2.0H,反应生成4-丁氧基苯甲酸
    参考文献:雷莫拉宁新半合成衍生物的合成和初步生物学表征.
    标题:雷莫拉宁新半合成衍生物的合成和初步生物学表征.
    摘要:雷莫拉宁是一种糖脂肽肽抗生素,对革兰氏阳性细菌(包括耐万古霉素的肠球菌)具有活性.雷莫拉宁通过不同于糖肽的机制抑制细菌细胞壁的生物合成,因此对这些抗生素没有交叉耐药性.到目前为止,由于静脉内注射时局部耐受性低,因此一直无法阻止雷莫拉汀的全身使用.为了克服这个问题,选择性去除了拉莫普林的脂肪酸侧链,并用各种不同的羧酸代替.许多新的雷莫拉宁衍生物显示出与天然前体相似的抗微生物活性,并具有明显改善的局部耐受性.
    Doi:10.1021/jm070042Z

    海关参考信息

    专利信息


    专利号:US-9453037-B2
    优先权日:2011-07-28
    标 题 :Methylphenidate-prodrugs, processes of making and using the same
    发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
    权利人:KEMPHARM INC; KEMPHARM INC
    摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:WO-2009131274-A1
    优先权日:2008-04-23
    标 题:Synthesis of photoinitiator free reactive mesogens based on triphenylene

    专利号:US-2008176857-A1
    优先权日:2005-03-25
    标题 :4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
    发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
    权利人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n n n n n n n n n n wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-2011152210-A1
    优先权日:2009-12-18
    标题 :Polyphenol compounds for inhibiting proteasome and uses thereof
    发明人:CHAN TAK-HANG; DOU Q PING
    权利人:UNIV MCGILL; UNIV HONG KONG POLYTECHNIC; UNIV WAYNE STATE
    摘要:Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for inhibiting proteasomal activity and for treating cancer is also provided.

    专利号:US-2014378541-A1
    优先权日:2011-06-16
    标题 :Synthetic Epigallocatechin Gallate (EGCG) Analogs
    发明人:CHAN TAK-HANG; PAMU SREEDHAR; DOU QING PING; CHEN DI
    权利人:CHAN TAK-HANG; PAMU SREEDHAR; DOU QING PING; CHEN DI; UNIV WAYNE STATE; UNIV MCGILL; UNIV HONG KONG POLYTECHNIC
    摘要:Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic disorders is also provided.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Rama Krishna Gudiminchi, Et Al. Identification And Characterization Of 4-Hexylbenzoic Acid And 4-Nonyloxybenzoic Acid As Substrates Of Cyp102A1. Appl Microbiol Biotechnol. 2011 Apr;90(1):117-26.

    合成参考文献


    参考文献:10.1007/s12210-025-01363-z
    摘要:Taher SR, Hamad WM, Omer RA, Hamad HQ, Salih SK. Potential of heterocyclic liquid crystals: a comprehensive review of their mesomorphic properties. Rend. Fis. Acc. Lincei. 2025 Aug 31;36(3):975–1001. doi: 10.1007/s12210-025-01363-z.
    参考文献:10.1007/s10812-025-02010-z
    摘要:Trisanjya R, Manepalli RKNR, Rao MC. Structural and Optical Properties of Liquid Crystalline Binary Mixtures with Dy3+ Phosphor Nanoparticles. J Appl Spectrosc. 2025 Nov;92(5):1079–85. doi: 10.1007/s10812-025-02010-z.
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