CAS: 14080-23-0; 2-Cyanopyrimidine

相似化合物

31519-62-7 27427-92-5 88511-48-2

上下游产品

2-chloropyrimidine trimethylamine pyrimidine-2-carboxamide pyrimidine N-oxide pyrimidine-2-carboxamidine N-phenyl-pyrimidine-2-carboximidic acid amideN-phenyl-pyrimidine-2-carboximidic acid amide (Z)-N'-hydroxy-pyrimidine-2-carboxamidine 2-acetylpyrimidine

2-氯嘧啶置于三乙烯二胺,Sodium Hydroxide体系中,用 水,二甲基亚砜 用作溶剂,化学反应生成2-氰基嘧啶
参考文献:Process For Making Pyrimidine Derivatives
标题:Process For Making Pyrimidine Derivatives
摘要:本发明提供了一种用于制备式i的嘧啶的方法:其中r.Sup.1,R.Sup.2,R.Sup.3分别独立表示氢,C.Sub.1-7-烷基或c.Sub.1-7-烷氧基,A表示-Cn,一个碳负离子r.Sup.4-炔基残基,其中r.Sup.4是氢或c.Sub.1-7-烷基,或者是式iii的丙二酸衍生物的碳负离子残基:其中b和b'独立表示-Cn,-Coor.Sup.5或-C(O)R.Sup.5,其中r.Sup.5是烷基或芳基.

专利信息

专利号:US-2003162992-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
发明人：WATANABE KYOICHI A; DU JINFA
摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

专利号:US-8492390-B2
优先权日:2002-05-08
标题 :Synthesis of locked nucleic acid derivatives
发明人：DETLEF SORENSEN MADS; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER
权利人:DETLEF SORENSEN MADS; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER; SANTARIS PHARMA AS
摘要:The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α- L -oxy-LNA, amino-LNA, α- L -amino-LNA, thio-LNA, α- L -thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues.

专利号:EP-1501848-B1
优先权日:2002-05-08
标 题 :Synthesis of locked nucleic acid derivatives
发明人：SORENSEN MADS DETLEF; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER
权利人:SANTARIS PHARMA AS
摘要:The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as alpha-L-oxy-LNA, amino-LNA, alpha-L-amino-LNA, thio-LNA, alpha-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues. (Formula I)

专利号:WO-2011116933-A1
优先权日:2010-03-24
标 题 :Process for the preparation of 2-substituted 4-amino-5-cyanopyrimidines
发明人：DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
权利人:LONZA AG; DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
摘要:A compound of the formula (I), wherein R 1 is C 1-4 alkyl or phenyl, is prepared by reacting a dicyanomethanide of the formula: M r n + [CH(CN) 2 ] rÌ… n (II), wherein M is an alkali or alkaline earth metal and r is 1 or 2, with carbon monoxide to obtain a dicyanoethenolate of the formula: M r n + [(NC) 2 C=CH–O] rÌ… (III), which is acylated to obtain an acyloxymethylenemalononitrile of the formula: (NC) 2 C=CH–OCOR 2 (IV), wherein R 2 is C 1-4 alkyl, which in turn is reacted with an amidine of the formula (V) to obtain the 4-amino-5-cyanopyrimidine of the formula (I). The compound of formula (I), wherein R is methyl, is an intermediate in a synthesis of thiamin (vitamin B 1 ).

专利号:US-7582748-B2
优先权日:2003-03-20
标题:Methods of manufacture of 2′-deoxy-β-L-nucleosides
发明人：RABI JAIME A
权利人:MICROBIOL QUIMICA FARMACEUTICA
摘要:The present invention relates to the synthesis of 2′-deoxy-β-L-thymidine, 2′-deoxy-β-L-uridine and 2′-deoxy-β-L-cytidine, and their derivatives, such as the 3′-O-acyl or 3′,5′-O-diacyl prodrugs, including the 3′-O-L-aminoacyl and 3′,5′-O-L-diaminoacyl prodrugs, and particularly the 3′-O-L-valinyl and 3′,5′-O-L-divalinyl prodrugs.

专利号:US-2012136015-A1
优先权日:2009-04-13
标题:Process for preparation of endothelial receptor antagonist (bosentan)
发明人：JOSHI SHREERANG; KHAN RASHID; BENDRE DEVEN; SALUNKHE DADASAHEB; GUDEKAR SANKET
权利人:JOSHI SHREERANG; KHAN RASHID; BENDRE DEVEN; SALUNKHE DADASAHEB; GUDEKAR SANKET; SANDOZ AG
摘要:The present invention relates to processes for the preparation of an endothelial receptor antagonist. The present invention particularly relates to synthesis of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide (bosentan).