CAS: 139013-68-6; (S)-4-Chlorobutane-1,3-Diol

相似化合物

86728-85-0 90866-33-4 88496-70-2

上下游产品

CAS号10488-69-4 4-氯-3-羟基丁酸乙酯 | CAS号86728-93-0 甲基 (S)-4-氯-3-羟基丁酸酯 | CAS号125781-04-6 (S)-4-chloro-3-... | CAS号86728-85-0 (S)-3-羟基-4-氯丁酸乙酯 | CAS号86087-23-2 (S)-(+)-3-羟基四氢呋喃

S(-)-4-氯-3-羟基丁酸乙酯置于sodium Tetrahydroborate体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应生成(S)-4-氯-1,3-丁二醇
参考文献:二聚吡喃萘醌一体化合成研究:多功能合成中间体的制备及对映-半-放线菌素和对映-半-γ-放线菌素的转化
标题:二聚吡喃萘醌一体化合成研究:多功能合成中间体的制备及对映-半-放线菌素和对映-半-γ-放线菌素的转化
摘要:为了开发二聚吡喃萘醌(包括 β-萘环酮,放线菌素和 γ-放线菌素)的通用合成方法,我们报告了立体定义的 6,9,10-三氧基吡喃萘醌作为一种多功能中间体.其稳定的制备过程是从 ( S )-4-氯-3-羟基丁酸乙酯开始的.吡喃萘核由michael-Dieckmann序列构建,并使用me 3 Al和bf 3 .oet 2甲基化以可扩展的方式建立所需的反式结构.还报道了将该中间体转化为对映-半-放线菌紫和对映-半-γ-放线菌紫,其中氧化内酯化的条件被优化.
Doi:10.1055/a-2124-4161

专利信息

专利号:US-6566525-B1
优先权日:1998-09-17
标 题:Preparation of N-substituted-hydroxycycloalkylamine derivatives
发明人：KIM SEONG JIN; KIM KEON IL; YANG KYOUNG YOUL
权利人:SAMSUNG FINE CHEMICALS CO LTD
摘要:A process for the preparation of N-substituted-hydroxycycloalkylamine derivatives, that are useful intermediates for the synthesis of various organic chemicals including pharmaceutical and agrochemical compounds, represented by formula (1), by reacting a 1,2-dihydroxalkyl alcohol, represented by the following formula (2), with a thionyl halide to produce an intermediate 1,2-cyclosulfinylalkyl halide represented by the following formula (3); and then cyclizing that intermediate with an amine compounds represented by the following formula (4).In the above structural formuli, * represents an asymmetric carbon atom; R1 is hydrogen or an amino-protecting group; m is an integer of 1-3; and X is halogen. The reactant compounds as well as the compounds made according to this invention have the following substitution pattern:n=1, R2=OH, R3=H and m=1; n=1, R2=H, R3=CH2OH and m=2;n=2, R2=OH, R3=H; and m=2; and n=2, R2=H, R3=CH2OH and m=3.

专利号:US-5144042-A
优先权日:1990-04-11
标题 :Process for preparing optically active 3-hydroxypyrrolidine derivatives
发明人：SEIDO NOBUO; OKEDA YOSHIKI; KUMOBAYASHI HIDENORI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:A process for preparing optically active 3-hydroxypyrrolidine derivatives useful as intermediates represented by formula (III): ##STR1## wherein Q represents a substituted or unsubstituted phenyl group; and * indicates an asymmetric carbon atom, comprising reacting an optically active 4-halo-3-hydroxybutane derivative represented by formula (I): ##STR2## wherein * is as defined above; R 1 represents a lower alkyl group or a substituted or unsubstituted phenyl group; and X represents a halogen atom, with a benzylamine derivative represented by formula (II): n n H.sub.2 NCH.sub.2 Q (II) n n wherein Q is as defined above, is disclosed. The starting compound (I) is easily available through chemical synthesis. Any complicated procedure or use of an expensive reagent is not required.