CAS: 13129-23-2; Methyl Furan-3-Carboxylate

该化合物是一种有机酯,产自呋喃-3-箱式酸,通常在制药和农用化学合成中用作多种用途的中间体,它的呋喃环形结构具有适合进一步功能化的回活动性,使其在循环循环化学中具有价值.在标准条件下,该化合物具有良好的稳定性,在普通有机溶剂中可溶解,便于在各种反应中使用.它的酯组增强了核生殖替代和凝聚反应中的回活动性,使高效衍生成为可能.甲基呋喃-3-箱式混合物对于生物活性分子,芳香和特殊化学品的制作特别有用.其定义明确的纯度和一贯性使得它成为研究和工业应用的可靠选择.

结构式图片

相似化合物

4412-91-3 498-60-2 488-93-7

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号22037-28-1 3-溴呋喃 | CAS号201230-82-2 carbon monoxide | CAS号67-56-1 甲醇 | CAS号488-93-7 3-糠酸;呋喃-3-甲酸 | CAS号77612-03-4 2-Oxabicyclo[3.... | CAS号743420-66-8 Ethanone, 2,2,2... | CAS号186581-53-3 重氮甲烷 | CAS号75-07-0 乙醛 | CAS号4412-91-3 3-呋喃甲醇 | CAS号83124-80-5 2,3-二氢-4-三氯乙酰基呋喃 | CAS号32365-53-0 5-甲酰基呋喃-3-羧酸乙酯

合成工艺路线路线简述

    三聚乙醛 以3%的收率获得3-呋喃甲酸甲酯
    参考文献:Process For The Preparation Of Furan Compounds
    标题:Process For The Preparation Of Furan Compounds
    摘要:以以下公式(1)表示的一个羰基化合物: 其中r1代表氢原子或一个有机基团;R2代表氢原子或一个有机基团,在公式(1)中与羰基团在键合位点上有一个碳原子,其中r1和r2可以结合形成与相邻两个碳原子的环,或其等效物与以下公式(2)表示的不饱和化合物发生反应: 其中每个r3,R4和r5代表氢原子,卤素原子,羟基或一个有机基团,其中r3和r4可以结合形成与相邻两个碳原子的环,或其前体,以产生以下公式(3)表示的呋喃化合物: 其中r3'代表r3,R5或氢原子;而r1,R2,R3,R4和r5如上定义.

    海关参考信息

    专利信息


    专利号:US-6258323-B1
    优先权日:1998-11-16
    标题:Apparatus and method used in multiple, simultaneous synthesis of general compounds
    发明人:HORMANN ROBERT EUGENE; GILBERT DARYL EUGENE; SIOMA EDWARD MICHAEL
    权利人:ROHM & HAAS
    摘要:The apparatus and method of the present invention provides for conducting simultaneous multiple synthesis of general compounds, which often takes place under varied uneven conditions requiring heating, cooling, agitation, reagent/solvent additions to the reactor contents at each reaction vessel location, supply and maintenance of inert atmosphere and means to facilitate the reflux of the reactor contents. Thus, it becomes necessary to monitor and control the reaction conditions during the simultaneous multiple synthesis of general compounds. The apparatus allows the user to connect various independently controlling and conveying means to each reaction vessel through multiple ports provided on a stopper mounted on each reaction vessel. The apparatus of the present invention permits user to readily access the reaction vessels without interrupting the reactions occurring in the adjacent reaction vessels. The unique geometry and shape of the stopper allows positioning of multiple ports, while still providing the stopper with a compact size. As a result, a large array of reaction vessels can be accommodated in the device of the present invention without significantly increasing the overall size of the apparatus. Some of the general compounds that can be readily synthesized by the apparatus and the method of the present invention include inorganic compounds as well as organic compounds, such as oligomers, polymers, agricultural chemicals, drugs, peptides and oligonucleotides.

    专利号:US-8221719-B2
    优先权日:2007-09-05
    标 题:Luminescent lanthanide (III) chelates, chelating agents and conjugates derived thereof
    发明人:PEURALAHTI JARI; HOVINEN JARI; KETOLA JANNE; JAAKKOLA LASSI; MUKKALA VELI-MATTI; LIITTI PAEIVI
    权利人:PEURALAHTI JARI; HOVINEN JARI; KETOLA JANNE; JAAKKOLA LASSI; MUKKALA VELI-MATTI; LIITTI PAEIVI; WALLAC OY
    摘要:This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.

    专利号:US-2008200475-A1
    优先权日:2005-03-28
    标题:4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors
    发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
    权利人:PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: (I) wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2a , R x , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9695191-B2
    优先权日:2009-08-05
    标题 :Conformationally constrained, fully synthetic macrocyclic compounds
    发明人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN
    权利人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN; POLYPHOR AG
    摘要:Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT 2B (5-HT 2B receptor), and on the prostaglandin F2•receptor (FP receptor). They are thus potentially useful for the treatment of hypomotility disorders of the gastrointestinal tract such as diabetic gastroparesis and constipation type irritable bowl syndrome; of CNS related diseases like migraine, schizophrenia, psychosis or depression; of ocular hypertension such as associated with glaucoma and preterm labour.
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    主要参考文献

    参考标题:Reductive Arene Ortho-Silanolization Of Aromatic Esters With Hydridosilyl Acetals
    作者:Yuanda Hua,Parham Asgari,Udaya Sree Dakarapu,Junha Jeon
    摘要:The Design And Application Of A Single-Pot, Reductive Arene C-H Bond Silanolization Of Esters For Synthesis Of Ortho-Formyl Arylsilanols.

    合成参考文献


    摘要:Jones, D. E.; Harmata, M., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 334.
    摘要:Yoshida, T.; Tobisu, M., Science of Synthesis: Special Topics, (2022) 1, 623.
    摘要:Kwiecień, H. U., Science of Synthesis: Knowledge Updates, (2024) 3, 164.
    摘要:Kwiecień, H. U., Science of Synthesis: Knowledge Updates, (2024) 3, 158.
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