CAS: 109113-72-6; 2-(Chloromethyl)-4-Methylquinazoline

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CAS号107-14-2 氯乙腈 | CAS号6640-59-1 2-(Chloromethyl... | CAS号70656-87-0 1,3-二氢-5-甲基-2H-... | CAS号853029-57-9 利拉利汀母核

2-(Chloromethyl)-4-Methylquinazoline 3-Oxide置于三氯化磷体系中,用 氯仿 用作溶剂,以57%的收率获得2-氯甲基-4-甲基喹唑啉
参考文献:[de] Neue 8-(Piperazin-1-yl)-Und 8-([1,4]Diazepan-1-yl)-Xanthine,Deren Herstellung Und Deren Verwendung Als Arzneimittel Novel 8-(Piperazine-1-yl)-And 8-([1,4]Diazepan-1-yl)-Xanthine,The Production And Use Thereof In The From Of A Drug[fr] Nouvelle Xanthine 8-(Piperazine-1-yl) Et 8-([1,4]Diazepan-1-yl),Sa Production Et Son Utilisation Comme Medicament
标题:[de] Neue 8-(Piperazin-1-yl)-Und 8-([1,4]Diazepan-1-yl)-Xanthine,Deren Herstellung Und Deren Verwendung Als Arzneimittel Novel 8-(Piperazine-1-yl)-And 8-([1,4]Diazepan-1-yl)-Xanthine,The Production And Use Thereof In The From Of A Drug[fr] Nouvelle Xanthine 8-(Piperazine-1-yl) Et 8-([1,4]Diazepan-1-yl),Sa Production Et Son Utilisation Comme Medicament
摘要:本发明涉及一种具有通式(i)的取代黄嘌呤,其中r1至r3和n如权利要求1至8中所定义,其互变异构体,对映体,非对映异构体,混合物,前药和盐,具有有价值的药理特性,特别是对二肽基肽酶-Iv(dpp-Iv)活性的抑制作用.

专利信息

专利号:WO-2015067539-A1
优先权日:2013-11-06
标 题:Process and intermediates for the preparation of linagliptin
发明人：GABOARDI MAURO; CASTALDI GRAZIANO; CASTALDI MARTA
权利人:CHEMELECTIVA S R L
摘要:The present invention relates to a process for the synthesis of Linagliptin and intermediates useful for its preparation.

专利号:US-12122754-B2
优先权日:2020-12-22
标题 :Related substance of linagliptin intermediate and synthesis method thereof
发明人：QIU XIAOLONG; WANG HU; XU TAO; HU LIN; ZOU PING; ZUO ZHIWEI; LIU WENBO; CHU LINGLING
权利人:WISDOM PHARMACEUTICAL CO LTD
摘要:A related substance of linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline, 4,4′-(2-methylpropane-1,3-diyl)bis(2-(chloromethyl)quinazoline) and a method for synthesizing the related substance (impurity) by reacting 2-(chloromethyl)-4-methylquinazoline with acetaldehyde under an alkaline condition and a purification method are provided. The preparation method is simple and convenient to operate, short in reaction time, high in product purity, and high in yield. The synthesized related substance can be used for qualitative and quantitative analysis of the linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline and API impurities of linagliptin, so that the medication safety of the linagliptin is improved.

专利号:US-2023010367-A1
优先权日:2020-12-22
标题 :Related substance of linagliptin intermediate and synthesis method thereof

专利号:WO-2022134488-A1
优先权日:2020-12-22
标题:Related substance of linagliptin intermediate and synthesis method therefor