CAS: 86484-91-5; 4-(2-((6-(Phenethylamino)Hexyl)Amino)Ethyl)Benzene-1,2-Diol Dihydrochloride

该化合物是一种化学化合物,其复杂结构特征包括一个带有氢氧化物组和顺流体矿链的苯环,该化合物一般是白色到非白色固体,由于盐形式的存在,可溶解于水中,从而增强盐的溶解性和稳定性;多种功能组的存在,包括氨和羟基,表明氢联结和再活的潜力,使其在各种生物化学应用中具有兴趣;该化合物可能展示生物活动,有可能影响细胞过程或在合成途径中作为前体;应当审查安全数据,以便处理和使用,如同任何化学品一样,确保采取适当的预防措施;

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物理性质

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合成工艺路线路线简述

  • 55536-65-7 + 73148-08-0 = 86484-91-5
    反应条件:1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane2.1 Reagents: Acetic Acid,Sodium Borohydride Solvents: Tetrahydrofuran; < 20 °C; 12 H,Reflux3.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 10 H,Rt
    标题:Concise Synthesis Of Dopexamine Dihydrochloride Via Benzyl Protecting Protocol
    作者:Guo,Yan; Et Al
    参考文献:Chinese Chemical Letters 日期:2015 卷标:26(3) 页码:357-360]

    1357466-62-6 = 86484-91-5
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 10 H,Rt
    标题:Concise Synthesis Of Dopexamine Dihydrochloride Via Benzyl Protecting Protocol
    作者:Guo,Yan; Et Al
    参考文献:Chinese Chemical Letters 日期:2015 卷标:26(3) 页码:357-360]

    = 86484-91-5
    反应条件:1.1 Reagents: Acetic Acid,Sodium Borohydride Solvents: Tetrahydrofuran; < 20 °C; 12 H,Reflux2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 10 H,Rt
    标题:Concise Synthesis Of Dopexamine Dihydrochloride Via Benzyl Protecting Protocol
    作者:Guo,Yan; Et Al
    参考文献:Chinese Chemical Letters 日期:2015 卷标:26(3) 页码:357-360]

    = 86484-91-5
    反应条件:1.1 Reagents: Acetic Acid,Sodium Borohydride Solvents: Tetrahydrofuran; < 20 °C; 12 H,Reflux2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 10 H,Rt
    标题:Concise Synthesis Of Dopexamine Dihydrochloride Via Benzyl Protecting Protocol
    作者:Guo,Yan; Et Al
    参考文献:Chinese Chemical Letters 日期:2015 卷标:26(3) 页码:357-360]

    = 86484-91-5
    反应条件:1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane; 2 H,Rt1.2 5 H,Rt2.1 Reagents: Acetic Acid,Sodium Borohydride Solvents: Tetrahydrofuran; < 20 °C; 12 H,Reflux3.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 10 H,Rt
    标题:Concise Synthesis Of Dopexamine Dihydrochloride Via Benzyl Protecting Protocol
    作者:Guo,Yan; Et Al
    参考文献:Chinese Chemical Letters 日期:2015 卷标:26(3) 页码:357-360]

    60-32-2 = 86484-91-5
    反应条件:1.1 Reagents: Dicyclohexylcarbodiimide,4-(Dimethylamino)Pyridine,N-Hydroxysuccinimide1.2 Reagents: Triethylamine2.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane3.1 Reagents: Acetic Acid,Sodium Borohydride Solvents: Tetrahydrofuran; < 20 °C; 12 H,Reflux4.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 10 H,Rt
    标题:Concise Synthesis Of Dopexamine Dihydrochloride Via Benzyl Protecting Protocol
    作者:Guo,Yan; Et Al
    参考文献:Chinese Chemical Letters 日期:2015 卷标:26(3) 页码:357-360]

    1699-60-1 = 86484-91-5
    反应条件:1.1 Reagents: Boron Trifluoride Etherate,Sodium Borohydride Solvents: Tetrahydrofuran; Rt; 12 H,Reflux2.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane3.1 Reagents: Acetic Acid,Sodium Borohydride Solvents: Tetrahydrofuran; < 20 °C; 12 H,Reflux4.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 10 H,Rt
    标题:Concise Synthesis Of Dopexamine Dihydrochloride Via Benzyl Protecting Protocol
    作者:Guo,Yan; Et Al
    参考文献:Chinese Chemical Letters 日期:2015 卷标:26(3) 页码:357-360

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主要参考文献

1. Bennett ED. Dopexamine: much more than a vasoactive agent. Crit Care Med. 1998 Oct;26(10):1621-2. doi: 10.1097/00003246-199810000-00002. 39(2):308-30. doi: 10.2165/00003495-199039020-00009. Erratum in: Drugs 1990 Aug;40(2):followi.

合成参考文献


参考文献:10.1007/bf01728334
摘要:Kawczynski P, Piotrowski A. Circulatory and diuretic effects of dopexamine infusion in low-birth-weight infants with respiratory failure. Intensive Care Med. 1996 Jan;22(1):65–70. doi: 10.1007/bf01728334.
参考文献:10.1186/cc2418
摘要:Asfar P, De Backer D, Meier-Hellmann A, Radermacher P, Sakka SG. Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock. Crit Care. 2004 Jun;8(3):170–9.
参考文献:10.1007/s001340050295
摘要:Guest JF, Boyd O, Hart WM, Grounds RM, Bennett ED. A cost analysis of a treatment policy of a deliberate perioperative increase in oxygen delivery in high risk surgical patients. Intensive Care Med. 1997 Jan;23(1):85–90. doi: 10.1007/s001340050295.
参考文献:10.1007/s00134-002-1322-6
摘要:Ralph CJ, Tanser SJ, Macnaughton PD, Sinclair DG. A randomised controlled trial investigating the effects of dopexamine on gastrointestinal function and organ dysfunction in the critically ill. Intensive Care Med. 2002 Jul;28(7):884–90. doi: 10.1007/s00134-002-1322-6.
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