CAS: 61521-74-2; (3R,4R)-3-Hydroxy-3,4-Bis(4-Hydroxy-3-Methoxybenzyl)Dihydrofuran-2(3H)-One

该化合物是天然来源的离子体化合物,以其潜在的生物活动而闻名,它具有显著的抗氧化剂和抗炎特性,成为药物研究中感兴趣的一个主题.以(+)-抗生素名称为标志,该化合物的手性纯度确保了对等选择性相互作用研究的一贯性;其定义明确的分子结构允许在实验应用中精确地定性和再生. (+)-诺列激素因其稳定性和高纯度,通常用于生物化学实验和分析化学中的参考标准.研究人员重视其在探索离子中间路径和治疗机制方面的作用.

英文名称(3R,4R)-3-Hydroxy-3,4-Bis(4-Hydroxy-3-Methoxybenzyl)Dihydrofuran-2(3H)-One
中文名称荛花酚
IUPAC名称(3R,4R)-3-hydroxy-3,4-bis(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
其它别名(3R)-3β,4α-Bis(3-Methoxy-4-Hydroxybenzyl)-3-Hydroxytetrahydrofuran-2-One; (3R,4R)-3,4-Bis(4-Hydroxy-3-Methoxybenzyl)-3-Hydroxy-4,5-Dihydrofuran-2(3H)-One; (3R,4R)-4,5-Dihydro-3,4-Bis(3-Methoxy-4-Hydroxybenzyl)-3-Hydroxyfuran-2(3H)-One; (3R,4R)-4,5-Dihydro-3-Hydroxy-3,4-Bis[(4-Hydroxy-3-Methoxyphenyl)Methyl]Furan-2(3H)-One; 2(3H)-Furanone, Dihydro-3-Hydroxy-3,4-Bis[(4-Hydroxy-3-Methoxyphenyl)Methyl]-, (3R,4R)-; (3R,4R)-3-Hydroxy-3,4-Bis(4-Hydroxy-3-Methoxybenzyl)Dihydrofuran-2(3H)-One; Phosphoinositide 3-Kinase,(+)-Nortrachelogenin,Inhibitor,Inhibit,Apoptosis,(+)Nortrachelogenin,Pi3K,(+) Nortrachelogenin; (+)-Nortrachelogenin, 10 Mm In Dmso
CAS编号61521-74-2
MFCD编号:MFCD01725924
FDA UNII编号:5HG1T9G09U
分子式:C20H22O7分子量:374.39
产品CID: 1597194
产品分类天然产物 → 木脂素

相似结构搜索
InChIKey: UMJZMTPNAOFXKT-XOBRGWDASA-N
InChI=1S/C20H22O7/c1-25-17-8-12(3-5-15(17)21)7-14-11-27-19(23)20(14,24)10-13-4-6-16(22)18(9-13)26-2/h3-6,8-9,14,21-22,24H,7,10-11H2,1-2H3/t14-,20-/m1/s1
计算化学: 氢键受体数7.0氢键供体数3.0可旋转键数6.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P305+P351+P338-
安全声明H303+H313+H333

上下游产品

(+)-O-dibenzylnortrachelogenine 1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene (2S,3R)-2-(4-Benzyloxy-3-methoxy-benzyl)-3-hydroxy-succinic acid (2S,3R)-2-(4-Benzyloxy-3-methoxy-benzyl)-3-hydroxy-succinic acid diisopropyl ester (-)-O-methyltrachelogenine (-)-O-dimethyltrachelogenine 7-hydroxysecoisolariciresinol dihydro-3-hydroxy-2(3H)-furanone3,4-bis(3,4-dimethoxyphenyl)methyldihydro-3-hydroxy-2(3H)-furanone

合成工艺路线路线简述

📜(+)-O-Dibenzylnortrachelogenine置于palladium On Activated Charcoal 氢气体系中,用乙醇,乙酸乙酯作为反应溶剂,化学反应 3.0H,反应生成荛花酚
参考文献:(-)-Trachelogenin,(-)-Nortrachelogenin和(+)-Wikstromol的总合成
标题:(-)-Trachelogenin,(-)-Nortrachelogenin和(+)-Wikstromol的总合成
摘要:通过相应的α,β-二苄基-γ-丁内酯(合成来源的木脂素)的α-羟基化获得标题化合物,并将其与(+/-)-甲基trachelogenin 9相关联,后者的相对结构通过x射线结晶成像法确定.因此,(-)-Trachelogenin 1和(-)-Nortrachelogenin 12具有(8S,8'S)绝对构型,而(+)-Nortrachelogenin 20(或wikstromol)具有(8R,8'R)绝对构型.
DOI:10.1016/s0040-4039(00)99653-9