CAS: 615-76-9; 6-Methyl-3-Thioxo-3,4-Dihydro-1,2,4-Triazin-5(2H)-One
该化合物是作为DNA四大主要组成部分之一的甲状腺的核核糖基模拟物;这一化合物的特征是硫磺原子,取代了在甲状胺中常见的氧原子;以及氮原子,替代了铁环中的碳原子;其结构改变具有独特的特性,使其对生化研究和潜在的治疗应用感兴趣;6-Aza-2-硫代苯的外表特征,如在某些条件下稳定性增强,氢结合能力改变,从而影响其与核糖酸的相互作用;此外,该化合物可能表现出与甲状核酸相比不同的溶性和再活性特征,影响其在各种化学和生物环境中的效用;该化合物作为亚基体或抑制剂在酶反应中发挥作用的能力,也是一项调查的主题,特别是在核酸代谢代谢研究以及抗病毒或抗癌剂的研制中.总体而言,6-亚硫代硫矿是探索核糖库功能和改变过程中的宝贵工具.
- 英文名称6-Methyl-3-Thioxo-3,4-Dihydro-1,2,4-Triazin-5(2H)-One
- 中文名称6-氮杂-2-硫代胸腺嘧啶
- IUPAC名称6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one
- 其它别名2-硫代-6-氮胸腺嘧啶; As-Triazine-3,5(2H,4H)-Dione, 6-Methyl-3-Thio- (8Ci)
- CAS编号615-76-9
- MFCD编号:MFCD00006458
- EINECS号:210-445-4
- FDA UNII编号:RHH0RIO9KF
- 分子式:C4H5N3OS分子量:143.17
- 产品CID: 1597928
- 产品分类有机原料→分子砌块→芳杂环类化合物→其它芳杂环类化合物
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(经皮)
急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2A - 警示词Warning(警告)
- 危险描述H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
- UN编号NONH for all modes of transport
- 危险品标志Xn
- 安全声明36/37/39-26-22-16
- 危险类别码20/21/22-11
- WGK Germany3
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号10418-09-4 Propanoic acid,... | CAS号617-35-6 丙酮酸乙酯 | CAS号79-19-6 硫代氨基脲 | CAS号22278-81-5 4-氨基-3-疏基-6-甲基-... | CAS号600-22-6 丙酮酸甲酯 | CAS号923-11-5 2-氧代丙酸异丙酯 | CAS号90997-76-5 6-methyl-3-prop... | CAS号143629-05-4 methyl 2-(carba... | CAS号1114-98-3 Propanoic acid,... | CAS号932-53-6 6-氮杂胸腺嘧啶 | CAS号1566-33-2 (6-methyl-5-oxo... | CAS号90997-76-5 6-methyl-3-prop... | CAS号90997-83-4 3-but-3-ynylsul...合成工艺路线路线简述
📜Ethyl 2-(2-Carbamothioylhydrazono)Propanoate置于sodium Hydroxide体系中,化学反应生成 6-氮杂-2-硫代胸腺嘧啶
参考文献:Gut,Collection Of Czechoslovak Chemical Communications,1958,Vol. 23,P. 1588,1589 Anm.,1590
标题:Gut,Collection Of Czechoslovak Chemical Communications,1958,Vol. 23,P. 1588,1589 Anm.,1590
专利信息
专利号:US-7229797-B1
优先权日:1999-08-20
标 题:Enzymatic synthesis of deoxyribonucleosides
发明人：TISCHER WILHELM; IHLENFELDT HANS-GEORG; BARZU OCTAVIAN; SAKAMOTO HIROSHI; PISTOTNIK ELISABETH; MARLIERE PHILIPPE; POCHET SYLVIE
权利人:PASTEUR INSTITUT
摘要:The present invention relates to a method for the in vitro enzymatic synthesis of deoxyribonucleosides and enzymes suitable for this method.
专利号:US-2008280329-A1
优先权日:1999-08-20
标 题 :Enzymatic synthesis of deoxyribonucleosides
专利号:US-2023053360-A1
优先权日:2021-08-11
标题:Nucleic acid-peptide-nucleic acid conjugate molecules and methods of making the same
发明人：STEPHANOPOULOS NICHOLAS; MACCULLOCH TARA
权利人:STEPHANOPOULOS NICHOLAS; MACCULLOCH TARA
摘要:The present disclosure relates to nucleic acid-peptide-nucleic acid conjugate molecules and to methods for synthesizing nucleic acid-peptide-nucleic acid conjugate molecules. In some embodiments, a method for synthesizing a nucleic acid-peptide-nucleic acid conjugate molecule using proximity-enhanced synthesis includes covalently linking a peptide with a first nucleic acid strand via a first reaction, hybridizing the first nucleic acid strand with a second nucleic acid strand to bring the second nucleic acid strand in proximity to the peptide, and covalently linking the peptide with the second nucleic acid strand via a second reaction to provide the nucleic acid-peptide-nucleic acid conjugate molecule. In some embodiments, the peptide of the nucleic acid-peptide-nucleic acid conjugate molecule is a substrate for cleavage by an enzyme, such as matrix metalloproteinase-8 (MMP-8). Exemplary applications of the nucleic acid-peptide-nucleic acid conjugate molecule for drug delivery, molecular assembly of hybrid structures, and constraining the peptide to a biologically active conformation are also disclosed.
专利号:CA-2382462-A1
优先权日:1999-08-20
标题:Enzymatic synthesis of deoxyribonucleosides
专利号:WO-0114566-A2
优先权日:1999-08-20
标 题 :Enzymatic synthesis of deoxyribonucleosides
专利号:EP-1206551-A2
优先权日:1999-08-20
标题:Enzymatic synthesis of deoxyribonucleosides
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis Of Thio Analogues Of Quinolone Antibacterials作者:Rahim Hekmat Shoar,Majid M. Heravi,Leila Pedram,Shadi Hasan Raeiat,Zeinab Jaddi |发布日期:2005.11.1
摘要:A Facile And Rapid Synthesis Of Thio Compounds, Analogues To Ciprofloxacin, And Norfloxacin Is Described.
合成参考文献
摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 416.
摘要:Archives Internationales de Pharmacodynamie et de Therapie., 95(123), 1953 []
摘要:K. Kalfus, Collect. Czech. Chem. Commun. 33, 2962 (1968).
摘要:J. Jonas and J. Gut, Collect. Czech. Chem. Commun. 27, 1886 (1962).
参考文献:10.1016/s1044-0305(02)00340-9
摘要:Mirgorodskaya E, O’Connor PB, Costello CE. A general method for precalculation of parameters for sustained off resonance irradiation/collision-induced dissociation. Journal of The American Society for Mass Spectrometry. 2002 Apr 01;13(4):318–24. doi: 10.1016/s1044-0305(02)00340-9.
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