CAS: 608-31-1; 2,6-Dichloroaniline

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CAS号601-88-7 2,6-二氯硝基苯 | CAS号56961-25-2 4-氨基-3,5-二氯苯甲酸 | CAS号2008-58-4 2,6-二氯苯甲酰胺 | CAS号697-88-1 4-溴-2,6-二氯苯胺 | CAS号94-09-7 对氨基苯甲酸乙酯 | CAS号41727-48-4 4-氨基-3,5-二氯苯甲酸甲酯 | CAS号619-45-4 4-氨基苯甲酸甲酯 | CAS号87-65-0 2,6-二氯苯酚 | CAS号22134-75-4 3,5-二氯磺胺 | CAS号111400-80-7 2-(2-bromopheny... | CAS号10286-88-1 N-(2,6-Dichloro... | CAS号50709-36-9 2,6-二氯苯肼盐酸盐 | CAS号56558-16-8 2,2,4,6,6-五氯联苯 | CAS号41464-46-4 2,3',4',6-四氯联苯 | CAS号41464-41-9 2,2',5,6'-四氯联苯 | CAS号41464-47-5 2,2',3,6'-四氯联苯 | CAS号3644-56-2 2-氯-n-(2,6-二氯苯基)乙酰胺 | CAS号393-79-3 2,4-二氯-3-氟硝基苯 | CAS号35065-29-3 2,2',3,4,4',5,5...

苯佐卡因置于氯体系中,用 3,5-二氯-4-氨基苯甲酸乙酯,水,氯苯 作为反应溶剂,化学反应生成 2,6-二氯苯胺
参考文献:Process For The Preparation Of 2,4-Or 2,6-Dihalogeno-Aniline
标题:Process For The Preparation Of 2,4-Or 2,6-Dihalogeno-Aniline
摘要:2,4-或2,6-二卤苯胺可以通过将式中r.Sup.1,R.Sup.2和r.Sup.3具有描述中指示的含义的氨基苯甲酸酯与2-2.5摩尔的氯化或溴化剂在惰性反应介质中在40-160摄氏度的温度下反应,然后水解和脱羧二卤氨基苯甲酸酯来制备.

专利信息

专利号:US-6420556-B1
优先权日:1998-12-17
标 题 :Acyl isothiocyanate resins and their use in solid-supported synthesis of guanidines
发明人：WILSON LAWRENCE JOSEPH
权利人:PROCTER & GAMBLE
摘要:The subject invention involves novel acyl isothiocyanate resins of formula (I) and processes for making them: (a) starting with a phenyl carboxy resin, treating the resin with any reagent that converts the carboxy to an acyl halide, followed by treatment with tetranikylammonium thiocyanate or an alkali metal salt thereof, to provide the acyl isothiocyanate resin. The subject invention also involves processes for making guanidine compounds and related cyclized compounds using an acyl isothiocyanate resin, comprising the following steps: (b) reacting the acyl isothiocyanate resin with a primary amine; (c) reacting the product from Step (b) with a sulfur activating agent and ammonia or a primary or secondary amine; (d) treating the product from Step (c) with a strong base or medium strength acid to cleave product from the resin, providing the guanidine compound or/and the related cyclized compound.

专利号:US-5243032-A
优先权日:1989-06-22
标题:Preparation of azo pigments with low pcb content by coupling in the presence of olefins
发明人：RIEPER WOLFGANG
权利人:HOECHST AG
摘要:The production which is customary in practice of monoazo compounds based on dichloro- and trichloroanilines or disazo compounds of the chlorinated biphenyl series by conventional coupling methods meets with difficulties in that the resulting pigments are contaminated by traces of polychlorinated biphenyls. n According to the invention, it has now been found that by addition of water-soluble olefins of the type ##STR1## (R =H, alk or Oalk; X =--COOR 1 , --CONHR 2 or --NR 3 COR 4 ) n in the azo coupling, the side reactions which form PCBs can be decidedly suppressed during synthesis of the pigments.

专利号:US-RE41998-E
优先权日:1990-02-26
标题 :Compositions and methods of treatment of sympathetically maintained pain
发明人：CAMPBELL JAMES N
权利人:ARCLON THERAPEUTICS INC
摘要:Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

专利号:US-4256639-A
优先权日:1978-06-23
标题:Process for the synthesis of isatin derivatives
发明人：BAIOCCHI LEANDRO
权利人:ACRAF
摘要:Process for the preparation of the 2-(2,6-dichloroanilino)-phenylacetic acid which comprises, as a basic step, the heating of a mixture containing a pyridic base, an organic or inorganic acid and 4,5,6,7-tetrahydro-N-(2,6-dichlorophenyl)-isatin or its O-acyl or O-alkyl derivatives.

专利号:US-10662145-B2
优先权日:2018-08-17
标题:Method of synthesizing diclofenac sodium
发明人：CHEN FENER; WANG LINGDONG; MENG GE; HUANG ZEDU; CHENG DANG; PENG HAIHUI; LIANG GUANFENG
权利人:UNIV FUDAN
摘要:The invention relates to the chemical synthesis of pharmaceutical API, and specifically to a method of synthesizing diclofenac sodium, which is a kind of nonsteroidal anti-inflammatory drug for relieving pain. The method includes: nitrating phenylacetate to prepare o-nitrophenylacetate (2); hydrogenating o-nitrophenylacetate (2) to prepare o-aminophenylacetate (3); amidating an amino group of o-aminophenylacetate (3) to obtain 2-(2-benzoylaminophenyl) acetate (4); 2-(2-benzoylaminophenyl) acetate (4) reacting with thionyl chloride to prepare a chloroimine intermediate, and then condensing the intermediate of chloroimine with 2,6-dichlorophenol using an inorganic base to prepare (E)-methyl-2-(2-((2,6-dichlorophenoxy)(phenyl)methyleneamino) phenyl ester (5); subjecting (E)-methyl-2-(2-((2,6-dichlorophenoxy)(phenyl)methyleneamino) phenyl ester (5) to Chapman rearrangement to afford methyl 2-(2-(N-(2,6-dichlorophenyl)benzoylamino)phenyl) ester (6); and hydrolyzing methyl 2-(2-(N-(2,6-dichlorophenyl)benzoylamino)phenyl) ester (6) to provide the target compound as of diclofenac sodium API. The overall yield is up to 67% based on methyl phenylacetate.

专利号:US-4656291-A
优先权日:1985-03-15
标 题 :Process for producing amidine sulfonic acids
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.