CAS: 59291-65-5; 2,3',4,4',5',6-Hexachlorobiphenyl

该化合物是一种多氯联苯同族体,其特点是在双联苯结构上有六种氯替代物,该化合物主要用于研究和分析应用,因为它是环境和毒理学研究的参考标准,其定义明确的化学特性和稳定性使它适合于校准分析仪器,如气相色谱-质谱测量(GC-MS),并适合于调查环境基质中的多氯联苯行为.该化合物的持久性和生物累积潜力也使其在研究长期生态影响和退化路径方面具有价值.由于国际环境协定下的毒性和监管地位,需要严格的处理程序.

英文名称2,3',4,4',5',6-Hexachlorobiphenyl
中文名称2,3',4,4',5',6-六氯联苯
IUPAC名称1,2,3-trichloro-5-(2,4,6-trichlorophenyl)benzene
其它别名2,3',4,4',5',6-Hexachlorobiphenyl
CAS编号59291-65-5
FDA UNII编号:783L7GB6V2
分子式:C12H4Cl6分子量:360.882
产品CID: 1569546
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: PITHIPNORFGJPI-UHFFFAOYSA-N
1S/C12H4Cl6/c13-6-3-7(14)11(8(15)4-6)5-1-9(16)12(18)10(17)2-5/h1-4H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

合成工艺路线路线简述

📜2,4,6-三氯苯胺,三氯苯置于亚硝酸异戊酯体系中,化学反应生成 2,3',4,4',5',6-六氯联苯
参考文献:Sandstroem,G.; Wachtmeister,C.A.,Acta Chemica Scandinavica (1947),1972,Vol. 26,P. 3816-3818
标题:Sandstroem,G.; Wachtmeister,C.A.,Acta Chemica Scandinavica (1947),1972,Vol. 26,P. 3816-3818