CAS: 5858-17-3; 1,2-Dichloro-4-Benzenethiol

该化合物是一种有机硫化合物,其特点是,在苯环上有一个直醇(-SH)组,该组在3和4个位置上有两个氯替代物.该化合物一般是一种无色的黄色液体,其气味强烈,不愉快,在有机溶剂中可溶解,但由于苯环具有疏水性,其溶解性有限.氯原子的存在增强了其再活动性,使其在有机合成和各种化学化合物生产中成为有用的中间体.3,4-二氯乙醇可以发生典型的硫醇反应,例如氧化成硫化物或与电击反应.重要的是要谨慎处理该化合物,因为它可能构成健康风险,包括皮肤和呼吸道刺激.在实验室或工业环境中与该物质打交道时,应当采取适当的安全措施.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

N-acetyl-S-(3,4-dichloro-phenyl)-L-cysteineN-acetyl-S-(3,4-dichloro-phenyl)-L-cysteine m,p-dichloroaniline 3,4-dichlorobenzenesulphonyl chloride 1,2,4-Trichlorobenzene 3,4-dichlorophenyl 4′-nitrophenyl sulfide 2-(3,4-dichloro-phenylsulfanyl)-5-nitro-benzoic acid chloromethyl 3,4-dichlorophenyl sulfide 1,2-dichloro-4-[(3,4-dichlorophenyl)disulfanyl]benzene

合成工艺路线路线简述

    N-乙酰基-S-(3,4-二氯苯基)-L-半胱氨酸置于sodium Hydroxide体系中,化学反应生成 3,4-二氯苯硫酚
    参考文献:Azouz Et Al.,Biochemical Journal,1955,Vol. 59,P. 410,411
    标题:Azouz Et Al.,Biochemical Journal,1955,Vol. 59,P. 410,411

    海关参考信息

    专利信息


    专利号:US-10150160-B2
    优先权日:2014-12-04
    标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles
    发明人:PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT
    权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A
    摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-2017326638-A1
    优先权日:2014-12-04
    标 题:Universal one-pot and up-scalable synthesis of sers encoded nanoparticles

    专利号:US-7002020-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:EP-3227037-A1
    优先权日:2014-12-04
    标 题:Universal one-pot and up-scalable synthesis of sers encoded nanoparticles
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    主要参考文献

    [参考文献]: Homan Kang, Et Al. Direct Identification Of On-Bead Peptides Using Surface-Enhanced Raman Spectroscopic Barcoding System For High-Throughput Bioanalysis. Sci Rep. 2015 May 28:5:10144.

    合成参考文献


    摘要:Patil, N. T.; Tathe, A. G.; Bhoyare, V. W., Science of Synthesis, (2019) , 127.
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