CAS: 552331-00-7; 4-Iodopyridin-2-Amine

相似化合物

20511-12-0 1062608-73-4 405939-28-8

上下游产品

CAS号22282-70-8 2-氟-4-碘吡啶 | CAS号504-29-0 2-氨基吡啶 | CAS号405939-28-8 (4-碘-吡啶-2-基)-氨基甲酸叔丁酯 | CAS号60-35-5 乙酰胺 | CAS号372-48-5 2-氟吡啶 | CAS号94805-51-3 1,2-二氢-2-氧代-4-吡啶甲腈 | CAS号690258-25-4 (7-碘[1,2,4]三氮唑并...

2-氨基吡啶置于sodium Periodate,硫酸,碘,溶剂黄146体系中,用 水 作为反应溶剂,化学反应 4.0H,以94%的收率获得产物4-碘吡啶-2-胺
参考文献:新型枫发色团类似物的合成和光学特性
标题:新型枫发色团类似物的合成和光学特性
摘要:摘要 合成了一种新型枫蛋白发色团衍生物.由于咪唑酮片段中共轭 π 系统的增加,与经典的 Kaede 发色团类似物相比,该化合物的吸收和发射最大值向长波区域移动.
DOI:10.1134/s1068162020010136

专利信息

专利号:WO-2023071314-A1
优先权日:2021-10-29
标 题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound

专利号:US-12331058-B2
优先权日:2021-10-29
标 题:SHP2 and CDK4/6 dual-target inhibitory compound and pharmaceutical composition containing the same
发明人：WU XIAOXING; CHEN XIAOYU; LI WENQIANG; Shu Chengxia; LUO GUANGMEI; YANG KEXIN
权利人:UNIV CHINA PHARMA
摘要:The present invention belongs to the field of medicinal chemistry, and particularly relates to synthesis, a preparation method and the use of an inhibitor containing dual targets SHP2 and CDK4/6, wherein the inhibitor comprises three compounds of general formulas I-III and pharmaceutically acceptable salts, enantiomers, diastereomers, tautomers, solvates, polymorphs or prodrugs thereof. According to the present invention, a class of brand-new SHP2 and CDK4/6 dual-target inhibitors are prepared by means of a pharmacophore fusion and reasonable drug design method, so that the problems of drug resistance, poor drug effect, etc., of the existing SHP2 inhibitor and CDK4/6 inhibitor are solved; the great significance of the present invention is providing the first SHP2 and CDK4/6 dual-target inhibitor, which provides a basis for solving the problem of drug resistance of kinase and phosphatase in the later period.

专利号:EP-4410794-A1
优先权日:2021-10-29
标题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound

专利号:CA-3236558-A1
优先权日:2021-10-29
标 题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound

专利号:CN-117143026-A
优先权日:2023-08-31
标题:A kind of synthesis method of heteroaryl trifluoromethyl compound

专利号:US-10858359-B2
优先权日:2016-06-07
标题 :Heterocyclic ring derivatives useful as SHP2 inhibitors
发明人：MA CUNBO; GAO PANLIANG; CHU JIE; WU XINPING; WEN CHUNWEI; KANG DI; BAI JINLONG; PEI XIAOYAN
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.