CAS: 54-47-7; (4-Formyl-5-Hydroxy-6-Methylpyridin-3-yl)Methyl Dihydrogen Phosphate

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41468-25-1 66-72-8 65-22-5

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CAS号529-96-4 吡哆胺5 '磷酸盐 | CAS号447-05-2 吡哆醇磷酸盐 | CAS号66-72-8 3-羟基-5-羟甲基-2-甲基... | CAS号524-36-7 盐酸吡多胺 | CAS号58-56-0 吡哆醇盐酸盐 | CAS号83825-03-0 (S)-(4-(((1-(do... | CAS号72343-06-7 pyridoxal benzo... | CAS号10524-83-1 (4-((hexylimino... | CAS号529-96-4 吡哆胺5 '磷酸盐 | CAS号75-07-0 乙醛 | CAS号127-17-3 丙酮酸 | CAS号447-05-2 吡哆醇磷酸盐 | CAS号7783-06-4 硫化氢 | CAS号7664-41-7 氨 | CAS号36120-58-8 1-(2-methyl-3-h... | CAS号954-27-8 4-pyridoxic aci... | CAS号412026-04-1 bis-(3-hydroxy-... | CAS号5913-68-8 (5-hydroxy-6-me...

吡哆醛盐酸盐置于水,三氯氧磷体系中,用 四氢呋喃 作为反应溶剂,化学反应 5.0H,反应生成 磷酸吡哆醛
参考文献:一种磷酸吡哆醛的合成方法
标题:一种磷酸吡哆醛的合成方法
摘要:本发明公开了一种合成磷酸吡哆醛(5'‑磷酸吡哆醛)的方法.该方法以盐酸吡哆辛为起始物,通过温和的反应条件氧化得到吡哆醛酸式盐,然后通过磷酸酯化试剂实行磷酸酯化反应,得到磷酸吡哆醛.本发明具有原料易得,路线简单,毒性小,副反应少,产物易分离,易于表征,产率高等特点.

专利信息

专利号:US-12421534-B2
优先权日:2021-11-10
标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs
发明人：ALMHJELL PATRICK J; ARNOLD FRANCES H
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.

专利号:US-11512303-B2
优先权日:2017-05-27
标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
发明人：CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-2025188502-A1
优先权日:2022-03-10
标 题 :Biocatalyst and method for the synthesis of ubrogepant intermediates
发明人：CHEN HAIBIN; HU HU; CAI BAOQIN; XU JUNPENG; LIU SITONG; JIN LUPING; WU XINWEI; CUI QINYAN; ZHANG CHENGXIAO; ZHU KAILONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:This application provides engineered transaminase polypeptides for the synthesis of Ubrogepant intermediates with high stereoselectivity, high catalytic activity and good stability. This application also provides a reaction process for the asymmetric synthesis of Ubrogepant intermediates using the transaminase polypeptide.

专利号:US-11168050-B2
优先权日:2014-03-27
标 题 :Efficient synthesis of amines and amides from alcohols and aldehydes by using cascade catalysis
发明人：CÓRDOVA ARMANDO; BERGLUND PER; ANDERSON MATTIAS; AFEWERKI SAMSON
权利人:XP CHEMISTRIES AB
摘要:The present invention relates generally to an eco-friendly methodology for the conversion of alcohols and aldehydes to amines and amides using an integrated enzyme cascade system with metal- and organocatalysis. More specifically, the present invention relates to synthesis of capsaicinoids starting from vanillin alcohol and using a combination of an enzyme cascade system and catalysts. Furthermore, the method also relates to synthesis of capsaicinoids derivatives starting from vanillin alcohol derivatives and using a combination of an enzyme cascade system and catalysts.

专利号:US-11459549-B2
优先权日:2018-05-10
标 题:Method for biocatalytic synthesis of Sitagliptin and intermediate thereof
发明人：WU FAHAO; YANG WEN; LI GANG; SHI HONGWEI; GAO YANGZHE; LIU LILI; YUAN ZHIFA
权利人:CHINA FORTUNE WAY COMPANY; NANJING REDWOOD FINE CHEMICAL CO LTD
摘要:Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.

专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.