CAS: 5116-24-5; 1-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-5-(Hydroxymethyl)Pyrimidine-2,4(1H,3H)-Dione

相似化合物

14599-46-3 4494-26-2 3424-98-4

上下游产品

formaldehyd 2'-deoxyuridine (5R,6R)-trans-(+)-5-bromo-6-hydroxy-5,6-dihydrothymidine trans-(5S,6S)-6-hydroxy-5-(2,2,6,6-tetramethyl-4-oxo-1-piperidinyl-N-oxide)-5,6-dihydrothymidine thymidine 5-acetoxymethyl-2'-deoxyuridine 5-(azidomethyl)-5'-azido-2',5'-dideoxyuridine 5-(azidomethyl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

📜Beta-胸苷置于吡啶,Ammonium Hydroxide,N-溴代丁二酰亚胺(Nbs),偶氮二异丁腈,氧气,Sodium Hydride体系中,用 1,4-二氧六环,N,N-二甲基甲酰胺,Mineral Oil,苯 作为反应溶剂,化学反应 33.0H,反应生成 5-羟甲基脱氧尿苷
参考文献:两种修饰核苷的缺氧选择性 Dna 链间交联形成
标题:两种修饰核苷的缺氧选择性 Dna 链间交联形成
摘要:干净的交叉代码:合成了两个硝基咪唑修饰的胸苷1A和1B,并将其整合到 Dna 寡聚体中.1A和1B的 350 Nm 光解产生 5-(2'-脱氧尿苷基)甲基自由基,诱导 Dna 链间交联(icl;见方案).在缺氧条件下观测到比在有氧条件下更高的 Icl 产量.
DOI:10.1002/chem.201201960

专利信息

专利号:US-8614312-B2
优先权日:2008-02-21
标 题 :Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared
发明人：PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE
权利人:PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER II
摘要:The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.

专利号:EP-0693287-A1
优先权日:1994-07-18
标 题:RNA cleaving or binding oligonucleotides
发明人：PEYMAN ANUSCHIRWAN DR; UHLMANN EUGEN DR
权利人:HOECHST AG
摘要:There are therapeutic agents for inhibiting protein synthesis containing two antisense oligonucleotides AO-1 and AO-2 with about 6-100 nucleotides, which bind to the target RNA at an adjacent site and at the 5 'end or 3' -Ends are linked via suitable spacers to conjugate molecules A and B, the conjugate molecules A and B each not being reactive per se, but brought into spatial proximity, forming a unit, and thus able to cleave the RNA catalytically or activated by the spatial proximity leads to the covalent binding of RNA.

专利号:CN-119954878-A
优先权日:2025-01-24
标 题 :Synthesis method of beta-D-glucosyl-5-hydroxymethyl uracil