CAS: 50329-91-4; 4-Chloro-2-Oxo-2H-Chromene-3-Carbaldehyde

上下游产品

4-hydroxy[1]benzopyran-2-one N,N-dimethyl-formamide N-methyl-N-phenylformamide 3-bromo-4-hydroxycoumarin 4-(N-allylanilino)-3-formyl-2(2H)-chromenone 6-(N-allylbenzylamino)-3-formyl[1]benzopyran-2(2H)-one -3-formyl-2(2H)-chromenone4--3-formyl-2(2H)-chromenone -3-formyl-2(2H)-chromenone4--3-formyl-2(2H)-chromenone

乙酸苯酯置于aluminum (Iii) Chloride,Sodium Hydride,三氯氧磷体系中,化学反应 9.0H,反应生成 4-氯-3-甲酰基香豆素
参考文献:2-氧代-2H-苯并二苯并-2-H-色烯基-5-氧代-2,5-二氢呋喃-3-羧酸酯的合成及抗炎活性.
标题:2-氧代-2H-苯并二苯并-2-H-色烯基-5-氧代-2,5-二氢呋喃-3-羧酸酯的合成及抗炎活性.
摘要:4-氯-2-氧代-2 H-亚甲基-3-甲醛(3A-G)和4-氯-2 H-亚甲基-3-甲醛(7A-H)与活化炔烃(4A-B)的环加成反应提供了2-Oxo-2 H-Chromenyl-5-Oxo-2,5-Dihydrofuran-3-羧酸盐(5A-N)和2 H-Chromenyl-5-Oxo-2,5-Dihydrofuran-3-羧酸盐(8A-P).筛选所有制备的化合物的抗炎活性.体外抗炎活性数据表明化合物5G,5I,5K-1和8F与标准化合物泼尼松龙(0.033+/-0.002 µm)相比,被测化合物对tnf-α(1.108+/-0.002,0.423+/-0.022,0.047+/-0.001,0.070+/-0.002和0.142+/-0.001 µm)有效.根据体外结果,已选择了三种化合物(5I,5K和8F)用于体内实验,在lps诱导的小鼠模型中,就抗炎活性而言,这些化合物被确定为更好的化合物.化合物5
DOI:10.1016/j.Bmcl.2020.127341

专利信息

专利号:US-10227355-B2
优先权日:2015-02-03
标题:Quinoline derivatives and preparation thereof
发明人：BALARAMAN EKAMBARAM; MIDYA SIBA PRASAD; JAISWAL GARIMA
权利人:COUNCIL SCIENT IND RES
摘要:The patent discloses novel quinoline derivatives of formula (I), (Formula should be inserted here) and process for preparing the same. The compounds of formula (I) can be further used for the synthesis of Inhibitors like Kinase Tyrosine Inhibitors.