CAS: 4480-83-5; Diglycolicanhydride

该化合物是来自地冰酸的环曲亚化物,其特点是能够进行水解,在水反应时形成地球酸.这种化合物一般是无色的,可粉黄液体,其沸点相对较低.以其反应性而著称,特别是形成酯和亚化物,使其在各种化学合成过程中有用.数字曲亚化物经常用于生产聚合物,树脂,并用作配制粘合剂和涂层的配方.此外,它具有中度毒性,需要适当的处理安全措施.它在有机溶剂中的溶性以及水溶性有限,进一步影响其在工业环境中的应用.

结构式图片

相似化合物

502-97-6 19500-95-9 57321-93-4

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上下游产品

2,2'-oxybis-acetic acid{2-[4-(3-chloro-4-methyl-phenyl)-piperazino]-2-oxo-ethoxy}-acetic acid (phenylcarbamoyl-methoxy)-acetic acid benzothiazol-2-ylmethoxy-acetic acid maleic anhydride

合成工艺路线路线简述

    二甘醇酸置于三氟乙酸酐体系中,用 乙酸乙酯 作为反应溶剂,化学反应 24.0H,以84%的收率获得产物二甘醇酐
    参考文献:Castagnoli-Cushman三组分反应的新杂环产物空间
    标题:Castagnoli-Cushman三组分反应的新杂环产物空间
    摘要:通过使用含有氧,氮和硫的内环取代的戊二酸酐类似物,已经实现了castagnoli-Cushman反应(ccr)可访问的杂环产物空间的显着扩展.将这些杂原子掺入酸酐的主链中可提高反应活性,并通常降低反应完成所需的温度.鉴于最近被认为是铅导向合成的有效工具的ccr,这些发现尤其重要.
    DOI:10.1021/acs.Orglett.5B02014

    海关参考信息

    专利信息


    专利号:US-2004152905-A1
    优先权日:2003-01-31
    标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-8415510-B2
    优先权日:2008-02-28
    标题 :Synthesis of a PEG-6 moiety from commercial low-cost chemicals
    发明人:ENGELL TORGRIM
    权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
    摘要:The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modified Boc-protected aminoxy PEG-6 linker was achieved so that said linker may be attached to a vector such as a peptide based fragment.

    专利号:US-8536375-B2
    优先权日:2008-12-22
    标题:Synthesis of obtaining modified polyethylene glycol intermediates
    发明人:ENGELL TORGRIM
    权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
    摘要:The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker.

    专利号:US-6159673-A
    优先权日:1996-07-17
    标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound
    发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI
    权利人:FUJI PHOTO FILM CO LTD
    摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.

    专利号:US-8519184-B2
    优先权日:2010-07-05
    标 题:Synthesis of rare earth metal extractant
    发明人:SAKAKI KAZUAKI; SUGAHARA HIROTO; OHASHI TETSUYA; KUME TETSUYA; IKKA MASAHIKO; NAGANAWA HIROCHIKA; SHIMOJO KOJIRO
    权利人:SAKAKI KAZUAKI; SUGAHARA HIROTO; OHASHI TETSUYA; KUME TETSUYA; IKKA MASAHIKO; NAGANAWA HIROCHIKA; SHIMOJO KOJIRO; SHINETSU CHEMICAL CO; NISSIN CHEMICAL IND
    摘要:A rare earth metal extractant in the form of a dialkyl diglycol amic acid is synthesized by reacting diglycolic anhydride with a dialkylamine in a synthesis medium. A molar ratio (B/A) of dialkylamine (B) to diglycolic anhydride (A) is at least 1.0. A non-polar or low-polar solvent in which the dialkyl diglycol amic acid is dissolvable is used as the synthesis medium.

    专利号:US-6469065-B1
    优先权日:1996-02-02
    标 题:Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
    发明人:GARVEY DAVID S; SCHROEDER JOSEPH D; DE TEJADA INIGO SAENEZ; GASTON RICKY D; SHELEKHIN TATIANA E; WANG TIANSHENG
    权利人:NITROMED INC
    摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.
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    主要参考文献

    [参考文献]: S M Kelleher, Et Al. Multivalent Linkers For Improved Covalent Binding Of Oligonucleotides To Dye-Doped Silica Nanoparticles. Nanotechnology. 2015 Sep 11;26(36):365703.

    合成参考文献


    摘要:Ulrich, H., Science of Synthesis, (2004) 17, 58.
    摘要:Schobert, R.; Gordon, G. J., Science of Synthesis, (2004) 27, 1016.
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